Results 201 to 210 of about 1,998,755 (305)

Unveiling the RNA viral diversity in three organs of the Asian house shrew (<i>Suncus murinus</i>) from Tropical Hainan, China: a previously underappreciated key zoonotic reservoir. [PDF]

Front Microbiol
Huangfu H, Pu J, Jiao M, Zhou H, Fan Q, Deng H, Ling Q, Luo X, Xu J.   +8 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Author Correction: VITAP: a high precision tool for DNA and RNA viral classification based on meta-omic data. [PDF]

Nat Commun
Zheng K, Sun J, Liang Y, Kong L, Paez-Espino D, Mcminn A, Wang M.   +6 more
europepmc   +1 more source

Remdesivir Influence on SARS-CoV-2 RNA Viral Load Kinetics in Nasopharyngeal Swab Specimens of COVID-19 Hospitalized Patients: A Real-Life Experience. [PDF]

Microorganisms, 2023
Campogiani L, Iannetta M, Di Lorenzo A, Zordan M, Pace PG, Coppola L, Compagno M, Malagnino V, Teti E, Andreoni M, Sarmati L.   +10 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Factors associated with HIV RNA viral non-suppression among children and adolescents with HIV attending public health facilities in Gulu City, Uganda: a retrospective cohort study. [PDF]

Ther Adv Infect Dis
Lanyero V, Bongomin F, Ebbs DS, Nantale R, Ochola E.   +4 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

VITAP: a high precision tool for DNA and RNA viral classification based on meta-omic data. [PDF]

Nat Commun
Zheng K, Sun J, Liang Y, Kong L, Paez-Espino D, Mcminn A, Wang M.   +6 more
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Zooming in and out: Exploring RNA Viral Infections with Multiscale Microscopic Methods. [PDF]

Viruses
Lyu CA, Shen Y, Zhang P.
europepmc   +1 more source