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Design of RNA-binding proteins and ligands

Current Opinion in Structural Biology, 2001
The rapidly expanding database of RNA structures and protein complexes is beginning to lead to the successful design of specific RNA-binding molecules. Recent combinatorial and structure-based approaches have utilized known nucleic-acid-binding scaffolds from both proteins and small molecules to display a relatively small set of functional groups often
Alan C. Cheng   +2 more
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Motif models for RNA-binding proteins

Current Opinion in Structural Biology, 2018
Identifying the binding preferences of RNA-binding proteins (RBPs) is important in understanding their contribution to post-transcriptional regulation. Here, we review the current state-of-the art of RNA motif identification tools for RBPs. New in vivo and in vitro data sets provide sufficient statistical power to enable detection of relatively long ...
Alexander Sasse   +3 more
openaire   +3 more sources

Single stranded RNA binding proteins

Current Opinion in Structural Biology, 2000
Our knowledge of protein interactions with RNA molecules has been, so far, largely restricted to cases in which the RNA itself is folded into a secondary and/or tertiary structure stabilised by intramolecular base pairing and stacking. Until recently, only limited structural information has been available about protein interactions with single-stranded
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RNA binding proteins in epilepsy

Gene Function & Disease, 2001
RNA binding proteins are involved in a diverse array of biological functions including mRNA transport, splicing, localization, stability and translation. Jerky is an RNA binding protein, complexed with mRNAs in neurons, that regulates mRNA utilization and consequently translation.
openaire   +2 more sources

Structures of RNA-binding proteins

Quarterly Reviews of Biophysics, 1997
Jean Cavarelli, John G. Arnez
openaire   +3 more sources

RNA Binding Proteins

2002
Kathryn Sandberg, Susan E. Mulroney
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The RNA-binding protein repertoire of embryonic stem cells

Nature Structural &Molecular Biology, 2013
S. -. Kwon   +10 more
semanticscholar   +1 more source

A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

Nature, 1997
Beilin Zhang   +6 more
semanticscholar   +1 more source

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