Results 271 to 280 of about 1,640,882 (289)

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

Arafat M, Gotea V, Umar MI, Muharram A, Kamhi E, Agami R, Sperling J, Hafner M, Elnitski L, Sperling R.   +9 more
europepmc   +1 more source

ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation. [PDF]

EMBO J
Watanabe Y, Suzuki N, Nakagawa T, Hosogane M, Akiyama T, Kageyama N, Funayama Y, Warita H, Morimoto S, Okano H, Aoki M, Nakayama K.   +11 more
europepmc   +1 more source

Data Sheet 1_Application of a novel RNA-protein interaction assay to develop inhibitors blocking RNA-binding of the HuR protein.docx

Larissa Filcenkova (20832338), Annika Reisbitzer (20832341), Benjamin Philipp Joseph (20832344), Verena Weber (1735129), Paolo Carloni (128984), Giulia Rossetti (471944), Sybille Krauß (258847)   +6 more
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Nuclear RNA-binding proteins meet cytoplasmic viruses. [PDF]

RNA
Castello A, Kamel W.
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Using circular RNAs to target toxic RNA-binding proteins in amyotrophic lateral sclerosis. [PDF]

Mol Ther Methods Clin Dev
Hollensen AK, Sørensen MH, Thomsen SV, Thomsen HS, Damgaard CK.   +4 more
europepmc   +1 more source

Integrative Approaches for DNA Sequence‐Controlled Functional Materials

Advanced Functional Materials, EarlyView.
DNA is emerging as a programmable building block for functional materials with applications in biomimicry, biochemical, and mechanical information processing. The integration of simulations, experiments, and machine learning is explored as a means to bridge DNA sequences with macroscopic material properties, highlighting current advances and providing ...
Aaron Gadzekpo, Ewa Anna Oprzeska‐Zingrebe, Mariana Kozlowska, Lennart Hilbert, Iliya D. Stoev   +4 more
wiley   +1 more source

RNA-binding proteins: a novel target for modulating glucose and lipid metabolism. [PDF]

Signal Transduct Target Ther
Hu Y, Sun Q.
europepmc   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source