Results 261 to 270 of about 803,841 (299)

Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)

2000
Approximately 170 million people world-wide are chronically infected with the hepatitis C virus (HCV) (BRADLEY et al. 1983; CHOO et al. 1989; HOUGHTON 1996; A;LTER 1997; also see Thomas, this volume). Although chronic infection with HCV frequently produces no symptoms for 5–30 years, it eventually has adverse effects on the host and constitutes a major
C H, Hagedorn, E H, van Beers, C, De Staercke   +2 more
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RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing

Science, 2002
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing.
openaire   +2 more sources

RNA-dependent RNA polymerases from flaviviruses and Picornaviridae

Current Opinion in Structural Biology, 2009
Flaviviruses and picornaviruses are positive-strand RNA viruses that encode the RNA-dependent RNA polymerase (RdRp) required for replicating the viral genome in infected cells. Because of their specific and essential role in the virus life cycle, RdRps are prime targets for antiviral drugs.
Julien, Lescar, Bruno, Canard
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Structural organization of viral RNA-dependent RNA polymerases

Biochemistry (Moscow), 2013
This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the ...
G S, Shatskaya, T M, Dmitrieva
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Biochemical characterization of rhinovirus RNA-dependent RNA polymerase

Antiviral Research, 2002
Human rhinoviruses (HRV) represent the single most important causative agent of the common cold. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) designated 3D polymerase that is required for replication of the HRV RNA genome. We have expressed and purified recombinant HRV-16 3D polymerase to near homogeneity from Escherichia coli ...
Magdeleine, Hung, Craig S, Gibbs, Manuel, Tsiang   +2 more
openaire   +2 more sources

Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)

2003
The hepatitis C virus (HCV) chronically infects approx 4 million patients in the United States alone, and constitutes a major cause of chronic liver disease and hepatocellular carcinoma (1-3). Current antiviral therapies for chronic hepatitis C remain relatively ineffective and have significant side-effects in many patients.
openaire   +2 more sources

Viral RNA-Dependent RNA Polymerases: A Structural Overview

2018
Most emerging and re-emerging human and animal viral diseases are associated with RNA viruses. All these pathogens, with the exception of retroviruses, encode a specialized enzyme called RNA-dependent RNA polymerase (RdRP), which catalyze phosphodiester-bond formation between ribonucleotides (NTPs) in an RNA template-dependent manner.
Diego, Ferrero, Cristina, Ferrer-Orta, Núria, Verdaguer   +2 more
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Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases

Nature Reviews Molecular Cell Biology, 2022
Mathias Girbig, Agata D Misiaszek, Christoph W Müller   +2 more
exaly  

RNA-Dependent RNA Polymerase (RdRp)

2023
openaire   +1 more source

Causes and consequences of RNA polymerase II stalling during transcript elongation

Nature Reviews Molecular Cell Biology, 2020
Melvin Jesus Noe Gonzalez, Daniel Blears, Jesper Qualmann Svejstrup   +2 more
exaly