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Contribution of critical amino acid residues in the RNA-dependent RNA polymerase to the replication fidelity and viral ribavirin sensitivity of porcine reproductive and respiratory syndrome virus. [PDF]
Vet ResZhang X +11 more
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TRIM56 restricts Coxsackievirus B infection by mediating the ubiquitination of viral RNA-dependent RNA polymerase 3D. [PDF]
PLoS PathogWang Y +13 more
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In silico Evaluation of H1-Antihistamine as Potential Inhibitors of SARS-CoV-2 RNA-dependent RNA Polymerase: Repurposing Study of COVID-19 Therapy. [PDF]
Turk J Pharm SciHamdan M, Kulabaş N, Küçükgüzel İ.
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Picornavirus RNA-dependent RNA polymerase
International Journal of Biochemistry and Cell Biology, 2009Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Peter C McMinn
exaly +3 more sources
Current Protocols in Molecular Biology, 2008
AbstractReverse transcriptases (RTs) are multifunctional enzymes, but are mainly used as RNA‐directed DNA polymerases in first‐strand cDNA synthesis. Specifically, oligodeoxynucleotides are used as primers for extension on RNA templates. The DNA synthesized from an RNA template is referred to as complementary DNA (cDNA) and is often used as a template ...
George, Tzertzinis +2 more
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AbstractReverse transcriptases (RTs) are multifunctional enzymes, but are mainly used as RNA‐directed DNA polymerases in first‐strand cDNA synthesis. Specifically, oligodeoxynucleotides are used as primers for extension on RNA templates. The DNA synthesized from an RNA template is referred to as complementary DNA (cDNA) and is often used as a template ...
George, Tzertzinis +2 more
openaire +2 more sources
RNA Editing with Viral RNA-Dependent RNA Polymerase
ACS Synthetic Biology, 2022RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR). However, this method only allows point editing.
Shinzi Ogasawara, Ai Yamada
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RNA-dependent RNA polymerases in RNA silencing
Biological Chemistry, 2011Abstract RNA-dependent RNA polymerases (RdRPs) synthesize double-stranded RNAs that are processed into small RNAs and mediate gene silencing. Viral RdRPs and cellular RdRPs show little structural homology to each other. Cellular RdRPs play key roles in RNA silencing by producing complementary strands for target RNAs via Dicer-dependent and -
Yoshiko, Maida, Kenkichi, Masutomi
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RNA-dependent RNA polymerases from Flaviviridae
Current Opinion in Structural Biology, 2009Viral genome replication in Flaviviridae is carried out by a virally encoded RNA-dependent RNA polymerase (RdRp). These viruses initiate the RNA synthesis via a de novo mechanism that differs from the primer-dependent mechanism used by Picornaviridae. Like all polymerases, the structure of Flaviviridae RdRps resembles a right hand with characteristic ...
Kyung H, Choi, Michael G, Rossmann
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