Results 1 to 10 of about 39,201 (181)

In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters

International Journal of Pharmaceutics: X, 2021
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 levels ...
Chaeho Moon, Zachary Warnken, Sawittree Sahakijpijarn   +2 more
exaly   +3 more sources

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

Pharmaceutics, 2020
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF).
Chaeho Moon, Sawittree Sahakijpijarn, John J Koleng   +2 more
exaly   +3 more sources

Clinical Outcomes of Remdesivir in Moderate and Severe Cases of COVID-19: A Retrospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Remdesivir is a nucleotide analogue prodrug that perturbs viral replication. Remdesivir has been used in various trials previously for the treatment of Coronavirus Disease 2019 (COVID-19).
Ruth Priya Senthiappan, Archana A Dambal, Mohan Kashinkunti, Kiran R Aithal, Rajendra Kumar Parakh, Bhargav Vuppumalla   +5 more
doaj   +1 more source

Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Purpose. Remdesivir and its active metabolite are predominantly eliminated via renal route; however, information regarding renal uptake transporters is limited.
Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano, Takaaki Abe, Hiroaki Yamaguchi   +4 more
doaj   +1 more source

Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys

Frontiers in Pharmacology, 2021
Aim: Kidney impairment is observed in patients with COVID-19. The effect of anti-COVID-19 agent remdesivir on kidneys is currently unknown. We aimed to determine the effect of remdesivir on renal fibrosis and its downstream mechanisms.Methods: Remdesivir
Lin Xu, Lin Xu, Lin Xu, Lin Xu, Bo Tan, Di Huang, Di Huang, Di Huang, Di Huang, Meijie Yuan, Meijie Yuan, Tingting Li, Tingting Li, Ming Wu, Ming Wu, Ming Wu, Ming Wu, Chaoyang Ye, Chaoyang Ye, Chaoyang Ye, Chaoyang Ye   +20 more
doaj   +1 more source

Remdesivir and Its Combination With Repurposed Drugs as COVID-19 Therapeutics

Frontiers in Immunology, 2022
The SARS-CoV-2 virus needs multiple copies for its multiplication using an enzyme RNA-dependent RNA polymerase (RdRp). Remdesivir inhibits viral RdRp, controls the multiplication of the virus, and protects patients.
Bhaswati Chatterjee, Suman S. Thakur
doaj   +1 more source

Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study.

PLoS ONE, 2021
ObjectivesRemdesivir is one of the most widely recommended and used medications for COVID-19 treatment. However, different outcomes have been reported for hospitalized patients with COVID-19 treated with remdesivir. Specifically, the effect of the timing
Hawra Ali Hussain Alsayed, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Ali Al Sayed Hussain, Qutayba Hamid, Rabih Halwani   +5 more
doaj   +2 more sources

The safety, tolerability and mortality reduction efficacy of remdesivir; based on randomized clinical trials, observational and case studies reported safety outcomes: an updated systematic review and meta-analysis

Therapeutic Advances in Drug Safety, 2021
Introduction: Remdesivir, an experimental antiviral drug has shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), both in vitro and in vivo .
Chenchula Santenna, Kota Vidyasagar, Krishna Chaitanya Amarneni, Sai Nikhila Ghanta, Balakrishnan Sadasivam, Saman Pathan, R. Padmavathi   +6 more
doaj   +1 more source

Co-Administration of Remdesivir and Azithromycin May Protect against Intensive Care Unit Admission in COVID-19 Pneumonia Requiring Hospitalization: A Real-Life Observational Study

Antibiotics, 2022
The benefits of remdesivir treatment, with or without co-administration of antibiotics such as azithromycin, are uncertain in COVID-19 pneumonia. The aim of this retrospective single-center study was to assess the effects of remdesivir, with or without ...
Andrea Ticinesi, Domenico Tuttolomondo, Antonio Nouvenne, Alberto Parise, Nicoletta Cerundolo, Beatrice Prati, Ilaria Zanichelli, Angela Guerra, Nicola Gaibazzi, Tiziana Meschi   +9 more
doaj   +1 more source

Remdesivir Strongly Binds to RNA-Dependent RNA Polymerase, Membrane Protein, and Main Protease of SARS-CoV-2: Indication From Molecular Modeling and Simulations

Frontiers in Pharmacology, 2021
Development of new drugs is a time-taking and expensive process. Comprehensive efforts are being made globally toward the search of therapeutics against SARS-CoV-2.
Faez Iqbal Khan, Tongzhou Kang, Haider Ali, Dakun Lai   +3 more
doaj   +1 more source