Results 231 to 240 of about 4,143,061 (301)

Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase. [PDF]

J Virol
Kalin JH, Yin Y, Tran MT, Piassek M, Fung A, Grosse S, Jacoby E, Bhaumik A, Adhikary S, Miller R, Lemmens C, Lutter FH, Pieters S, Cooymans L, Rombouts G, Oehlrich D, Tomaso S, Lozada K, Garcia MO, Anson B, De Bruyn S, Smith-Monroy C, Neefs J-M, Conceição-Neto N, Stoops B, van Vlijmen H, Patrick A, Yu X, Wong V, Krosky D, Abeywickrema P, Mason S, Jin Z, Jonckers THM, Sharma S.   +34 more
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Structure-function analysis of the RNA polymerase III subcomplex C17/25 and genome-wide distribution of RNA polymerase II [PDF]

, 2009
Jasiak, A., Jasiak, Anna Justyna
core   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach. [PDF]

ACS Infect Dis
Malune P, Iaconis D, Manelfi C, Giunta S, Emmolo R, Lunghini F, Paulis A, Talarico C, Corona A, Beccari AR, Tramontano E, Esposito F.   +11 more
europepmc   +1 more source

A5—A dual-target antiviral compound that rewrites the rules of influenza therapy

Acta Pharmaceutica Sinica B
Shibo Jiang
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase. [PDF]

Protein Sci
Danda M, Klimešová A, Kušková K, Dostálková A, Pagáčová A, Prchal J, Kapisheva M, Ruml T, Rumlová M.   +8 more
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Mechanism of Inhibition of the Active Triphosphate Form of 2'-α-Fluoro,2'-β-bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase. [PDF]

ACS Infect Dis
Gordon CJ, Walker SM, LeCher JC, Amblard F, Schinazi RF, Götte M.   +5 more
europepmc   +1 more source