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Picornavirus RNA-dependent RNA polymerase
The International Journal of Biochemistry & Cell Biology, 2009Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Peter C. McMinn, Chee Choy Kok
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RNA-dependent RNA polymerases in RNA silencing
Biological Chemistry, 2011Abstract RNA-dependent RNA polymerases (RdRPs) synthesize double-stranded RNAs that are processed into small RNAs and mediate gene silencing. Viral RdRPs and cellular RdRPs show little structural homology to each other. Cellular RdRPs play key roles in RNA silencing by producing complementary strands for target RNAs via Dicer-dependent and -
Yoshiko Maida, Kenkichi Masutomi
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RNA Editing with Viral RNA-Dependent RNA Polymerase
ACS Synthetic Biology, 2022RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR). However, this method only allows point editing.
Shinzi Ogasawara, Ai Yamada
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RNA-dependent RNA polymerases from Flaviviridae
Current Opinion in Structural Biology, 2009Viral genome replication in Flaviviridae is carried out by a virally encoded RNA-dependent RNA polymerase (RdRp). These viruses initiate the RNA synthesis via a de novo mechanism that differs from the primer-dependent mechanism used by Picornaviridae. Like all polymerases, the structure of Flaviviridae RdRps resembles a right hand with characteristic ...
Kyung H. Choi, Michael G. Rossmann
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RNA-dependent RNA polymerase in Chinese cabbage
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract An RNA-dependent RNA polymerase which incorporates nucleotides from ribonucleoside triphosphates into an acid-insoluble polymer has been purified from the chloroplastic fraction of Chinese cabbage leaves. 1. 1. Addition of RNA template is required for enzymatic activity; the synthetic polynucleotide poly (U, C) and TYMV-RNA are among the
S Astier-Manifacier, P Cornuet
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An RNA-dependent RNA polymerase is required for paramutation in maize [PDF]
Nature, 2006 Paramutation is an allele-dependent transfer of epigenetic information, which results in the heritable silencing of one allele by another. Paramutation at the b1 locus in maize is mediated by unique tandem repeats that communicate in trans to establish and maintain meiotically heritable transcriptional silencing.
Lyudmila Sidorenko +10 more
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L protein, the RNA-dependent RNA polymerase of hantaviruses
Archives of Virology, 2004L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms ...
Alexander Plyusnin +2 more
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DNA- and RNA-dependent DNA polymerases
Current Opinion in Structural Biology, 1993Abstract A catalytic subdomain of HIV reverse transcriptase has the same structure as that of E. coli Klenow fragment, including three conserved carboxylates whose mutation destroys activity. The structures of Klenow fragment complexed with DNA and with divalent metal ions, taken together with mutagenic studies, are consistent with a two-metal-ion ...
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RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing
Science, 2002Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing.
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RNA-dependent RNA polymerases from flaviviruses and Picornaviridae
Current Opinion in Structural Biology, 2009Flaviviruses and picornaviruses are positive-strand RNA viruses that encode the RNA-dependent RNA polymerase (RdRp) required for replicating the viral genome in infected cells. Because of their specific and essential role in the virus life cycle, RdRps are prime targets for antiviral drugs.
Julien Lescar, Bruno Canard
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