Results 341 to 350 of about 763,502 (351)

Structural organization of viral RNA-dependent RNA polymerases

Biochemistry (Moscow), 2013
This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the ...
G. S. Shatskaya, T.M. Dmitrieva
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Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

Nature, 1970
Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of genetic transcription: apparently the classical process of ...
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Viral RNA-Dependent RNA Polymerases: A Structural Overview

2018
Most emerging and re-emerging human and animal viral diseases are associated with RNA viruses. All these pathogens, with the exception of retroviruses, encode a specialized enzyme called RNA-dependent RNA polymerase (RdRP), which catalyze phosphodiester-bond formation between ribonucleotides (NTPs) in an RNA template-dependent manner.
Cristina Ferrer-Orta, Diego S. Ferrero, Núria Verdaguer   +2 more
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Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase) [PDF]

, 2000
Approximately 170 million people world-wide are chronically infected with the hepatitis C virus (HCV) (BRADLEY et al. 1983; CHOO et al. 1989; HOUGHTON 1996; A;LTER 1997; also see Thomas, this volume). Although chronic infection with HCV frequently produces no symptoms for 5–30 years, it eventually has adverse effects on the host and constitutes a major
Curt H. Hagedorn, C. De Staercke, E. H. van Beers   +2 more
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Biochemical characterization of rhinovirus RNA-dependent RNA polymerase

Antiviral Research, 2002
Human rhinoviruses (HRV) represent the single most important causative agent of the common cold. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp) designated 3D polymerase that is required for replication of the HRV RNA genome. We have expressed and purified recombinant HRV-16 3D polymerase to near homogeneity from Escherichia coli ...
Magdeleine Hung, Manuel Tsiang, Craig S. Gibbs   +2 more
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Isolation and Analysis of Plant RNA-Dependent RNA Polymerases

2012
RNA-dependent RNA polymerases (RDRPs) are encoded by RNA viruses as well as eukaryotic organisms such as plants. The function of these cellular RDRPs has been associated with the synthesis of short interfering RNAs (siRNAs), which are essential regulators of genomic integrity and plant viral defense. The multiple gene copies, and functional diversities,
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Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)

2003
The hepatitis C virus (HCV) chronically infects approx 4 million patients in the United States alone, and constitutes a major cause of chronic liver disease and hepatocellular carcinoma (1-3). Current antiviral therapies for chronic hepatitis C remain relatively ineffective and have significant side-effects in many patients.
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An Assay for RNA-Dependent RNA Polymerase Activity

Cold Spring Harbor Protocols, 2006
Craig E. Cameron, John Gledhill, Luyun Huang   +2 more
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Assay for Primed RNA-Dependent RNA Polymerase Transcription

Cold Spring Harbor Protocols, 2006
John Gledhill, Craig E. Cameron, Luyun Huang   +2 more
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RNA-dependent RNA polymerase activity of the influenza virus

Virology, 1971
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