Results 91 to 100 of about 34,592 (189)

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

Advances towards norovirus antivirals [PDF]

, 2016
Human noroviruses are a leading cause of gastroenteritis worldwide, yet there are no licensed antivirals. There is an urgent need for norovirus therapeutics, particularly for chronic infections in immunocompromised individuals, but also a potential need ...
Arias, Armando, Goodfellow, Ian, Thorne, Lucy   +2 more
core   +1 more source

ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The bacteriophages with single‐stranded RNA (ssRNA) genomes (class Leviviricetes) are among the simplest known viruses that encode only three core proteins: a receptor‐binding protein, a capsid protein, and an RNA‐dependent RNA polymerase. The number of isolated ssRNA phages has remained very low, but the accumulating RNA metagenome data have ...
Jānis Rūmnieks, Ieva Baltā, Mihails Šišovs, Kaspars Tārs   +3 more
wiley   +1 more source

Architecture of a SARS-CoV-2 mini replication and transcription complex

Nature Communications, 2020
SARS-CoV-2 virus replication and transcription is mediated by the replication and transcription complex (RTC) that is composed of 16 non-structural proteins (nsp). Here, the authors present the cryo-EM structure of a SARS-CoV-2 mini RTC consisting of the
Liming Yan, Ying Zhang, Ji Ge, Litao Zheng, Yan Gao, Tao Wang, Zhihui Jia, Haofeng Wang, Yucen Huang, Mingyu Li, Quan Wang, Zihe Rao, Zhiyong Lou   +12 more
doaj   +1 more source

Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase

iScience, 2020
Summary: COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently being treated using Remdesivir, a nucleoside analog that inhibits the RNA-dependent-RNA polymerase (RdRp).
Tyler L. Dangerfield, Nathan Z. Huang, Kenneth A. Johnson   +2 more
doaj   +1 more source

Widespread mitovirus sequences in plant genomes [PDF]

PeerJ, 2015
The exploration of the evolution of RNA viruses has been aided recently by the discovery of copies of fragments or complete genomes of non-retroviral RNA viruses (Non-retroviral Endogenous RNA Viral Elements, or NERVEs) in many eukaryotic nuclear genomes.
Jeremy A. Bruenn, Benjamin E. Warner, Pradeep Yerramsetty   +2 more
doaj   +2 more sources

PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection [PDF]

, 2012
BACKGROUND: Although gene exchange is not likely to occur freely, reassortment between the H5N1 highly pathogenic avian influenza virus (HPAIV) and currently circulating human viruses is a serious concern.
Buchy, Philippe, Deubel, Vincent, Jiang, Hongbing, Kohara, Michinori, Mao, Yingying, Sekiguchi, Satoshi, Sun, Bing, Toyoda, Tetsuya, Wang, Jinlan, Wang, Qiang, Weng, Leiyun, Xu, Ke, Yasui, Fumihiko, Zhang, Shijian   +13 more
core   +3 more sources

Molecular Detection of Alpha‐ and Betacoronaviruses in Bats from Afar Region, Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Bats are critical reservoirs of coronaviruses, yet gaps remain in understanding coronavirus diversity within bat populations in Eastern Ethiopia. A total of 141 bats were captured: 129 Chaerephon pumilus, 11 Epomophorus labiatus and 1 Mops condylurus. Coronaviruses detected in eight bats.
Bula Mengesha, Gebremedhin Romha, Gebremedhin Gebrezgabiher   +2 more
wiley   +1 more source

Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. [PDF]

PLoS Pathogens, 2013
The flavivirus NS5 harbors a methyltransferase (MTase) in its N-terminal ≈ 265 residues and an RNA-dependent RNA polymerase (RdRP) within the C-terminal part.
Guoliang Lu, Peng Gong
doaj   +1 more source