Results 81 to 90 of about 4,271,507 (162)

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

, 2021
All RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which in arteriviruses is expressed as the C-terminal domain of nonstructural protein 9 (nsp9).
Lehmann K.C.
core  

Molecular basis of RNA-dependent RNA polymerase II activity. [PDF]

, 2007
RNA polymerase (Pol) II catalyses DNA-dependent RNA synthesis during gene transcription. There is, however, evidence that Pol II also possesses RNA-dependent RNA polymerase (RdRP) activity.
Lehmann, E., Cramer, P., Brueckner, Florian, Brueckner, F., Cramer, Patrick, Lehmann, Elisabeth   +5 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase [PDF]

, 2002
The first 11 nt at the 5' end of influenza virus genomic RNA were shown to be both necessary and sufficient for specific binding by the influenza virus polymerase.
Tiley, Laurence, Digard, Paul, Medcalf, Liz, Bishop, Konrad, Elton, Debra, Lee, Michael T   +5 more
core  

Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea. [PDF]

, 2009
Contains fulltext : 80405.pdf (Publisher’s version ) (Open Access)One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the ...
Makarova, K.S., Siebers Bettina, Koonin Eugene V, Bettina Siebers, Siebers, B.G., Kira S Makarova, Blombach Fabian, Fabian Blombach, Makarova Kira S, John Oost, Koonin, E.V., Oost, J., van der, Siebers, B., Marrero, J., Oost John, Blombach, F., Oost, J. van der, Marrero Jeannette, Jeannette Marrero, Eugene V Koonin   +19 more
core   +1 more source

RNA Editing with Viral RNA-Dependent RNA Polymerase

, 2022
RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR).
Shinzi Ogasawara (2426575), Ai Yamada (1730698), Ai Yamada, Shinzi Ogasawara   +3 more
core   +1 more source

Metagenomic detection and characterization of RNA viruses associated with Rhipicephalus linnaei (Audouin, 1826) ticks from the Amazon, Pará, Brazil

Medical and Veterinary Entomology, EarlyView.
Metagenomic analysis of Rhipicephalus linnaei from the Brazilian Amazon revealed the presence of RNA viruses belonging to the families Chuviridae, Phenuiviridae, Orthomyxoviridae and Rhabdoviridae. This study reports the first detection of Brown dog tick mivirus 1 and Brown dog tick phlebovirus 2 in Brazil, based on genomic characterization and ...
Lucas Henrique da Silva e Silva, Sandro Patroca da Silva, Fábio Silva da Silva, Leonardo Henrique Almeida Hernández, Daniel Damous Dias, Sâmia Luzia Sena da Silva, Lúcia Aline Moura Reis, Hanna Carolina Farias Reis, Bruna Laís Sena do Nascimento, Roberto Carlos Feitosa Brandão, Durval Bertram Rodrigues Vieira, Bruno Tardelli Diniz Nunes, Ana Cecília Ribeiro Cruz, Joaquim Pinto Nunes Neto   +13 more
wiley   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source

Therapeutic and Prophylactic Agents for Viral Diseases: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 11, November 2026.
This review summarizes current therapeutic and prophylactic strategies for global viral diseases, including vaccines, PrEP, direct‐acting antivirals, and emerging modalities such as CRISPR and siRNA. It highlights their clinical impact, ongoing challenges, and future priorities toward broader protection, improved delivery, and more effective antiviral ...
Sawar Khan, Ayesha Nisar, Xiaoxu Li, Hao Yu, Abdul Qadeer, Sardar Azhar Mehmood, Imane Lamraoui, Sijie Liu, Lipeng Zhu, Xu Deng, Bo Kong, Kejun Zhong, Zanxian Xia   +12 more
wiley   +1 more source

The structure of a dimeric form of SARS-CoV-2 polymerase

Communications Biology, 2021
Jochheim et al report an alternative, dimeric form of the coronavirus SARS-CoV-2 RNA dependent RNA polymerase (RdRp), which is used to replicate and transcribe its genome.
Florian A. Jochheim, Dimitry Tegunov, Hauke S. Hillen, Jana Schmitzová, Goran Kokic, Christian Dienemann, Patrick Cramer   +6 more
doaj   +1 more source