Results 81 to 90 of about 57,300 (174)

Virtual Screening for Possible Allosteric Inhibitors of Dengue RNA-dependent RNA polymerase (RdRp)

Philippine Journal of Health Research and Development, 2015
Background and Objective: Virtual screening involves the docking of databases containing the structures of small molecules into a region of interest in silico and the scoring of ligands according to their predicted target site interactions.
Ariane Marielle F. Valle, Erika A. Macalalad, Joanna Liezl A. Abrina, Ernest Jay V. Cafino, Thatcher M. Pancho, Junie B. Billones   +5 more
openaire   +1 more source

Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation

, 2010
The RNA interference (RNAi) pathway in Caenorhabditis elegans is a two-step, small RNA-mediated silencing pathway. Unlike in other organisms, Dicer processing of double-stranded RNA into small interfering (si) RNAs is not sufficient in worms to induce ...
Vasale, Jessica J.
core   +1 more source

Characterization of cucumber mosaic virus RNA-dependent RNA polymerase

, 1991
Cucumber mosaic virus (CMV) RNA-dependent RNA polymerase (RdRp) was purified form CMV-infected tobacco. The purified enzyme is completely dependent an exogenous template.
Quadt, R., Jaspars, E.M.J., E.M.J. Jaspars, R. Quadt   +3 more
core   +1 more source

Remdesivir Strongly Binds to both RNA-dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations

, 2020
The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–coronavirus 2) has caused a global CoVid-19 (coronavirus disease 2019) pandemic, resulting in millions of infections and thousands of deaths around the world.
Duc Toan, Truong, Hoang Linh, Nguyen, Thai, Nguyen, Mai Suan, Li   +3 more
core   +1 more source

In silico study of RNA polymerase inhibitor drugs for Rift Valley fever virus using RdRp protein as the target

Context: Rift Valley fever (RVF) is a disease caused by the RVF virus (RVFV), concentrated mostly in Africa. The virus, usually found in animals, can infect humans through contact with infected animals or mosquito vectors. No established treatment exists,
Mukti Subagja, Juan Lorell, Theophanie Scholastica Tanzil, Arli Aditya Parikesit, Nicolaas Raditya Putra Gautama   +4 more
core   +1 more source

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive

, 2021
All RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which in arteriviruses is expressed as the C-terminal domain of nonstructural protein 9 (nsp9).
Lehmann K.C.
core  

Remdesivir-Bound and Ligand-Free Simulations Reveal the Probable Mechanism of Inhibiting the RNA Dependent RNA Polymerase of SARS-CoV-2

, 2020
The efforts towards developing a potential drug against the current global pandemic, COVID-19, has increased in the past few months. Drug development strategies to target the RNA dependent RNA polymerase (RdRP) are being tried worldwide.
Uddhavesh, Sonavane, Rajendra, Joshi, Shruti, Koulgi, Vinod, Jani, Mallikarjunachari, Uppuladinne V N   +4 more
core   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč, Jan Drahorád, Jakub Harvalík, Tereza Horáčková, Manfred Brinker, Arianna Loregian, Andrea Brancale, Beatrice Mercorelli, Petra Cuřínová   +8 more
wiley   +1 more source

Next generation sequencing for studying viruses and RNA silencing-based antiviral defense in crop plants [PDF]

, 2014
The main objectives of this work have been to use next generation sequencing (NGS) and develop bioinformatics tools for plant virus diagnostics and genome reconstruction as well as for investigation of RNA silencing-based antiviral defense.
Seguin, Jonathan
core   +1 more source

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

Journal of Medical Virology, 2020
An outbreak of coronavirus disease 2019 (COVID‐19) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For coronaviruses, RNA‐dependent RNA polymerase (RdRp) is an important polymerase that catalyzes the replication of RNA from ...
Jrhau Lung, Yu-Shih Lin, Yao-Hsu Yang, Yu-Lun Chou, Li-Hsin Shu, Yu-Ching Cheng, Hung-Te Liu, Ching-Yuan Wu   +7 more
semanticscholar   +1 more source