Results 61 to 70 of about 57,300 (174)

Intermolecular Interaction Among Remdesivir, RNA and RNA-Dependent RNA Polymerase of SARS-CoV-2 Analyzed by Fragment Molecular Orbital Calculation

, 2020
COVID-19, a disease caused by a new strain of coronavirus (SARS-CoV-2) originating from Wuhan, China, has now spread around the world, triggering a global pandemic, leaving the public eagerly awaiting the development of a specific medicine and vaccine ...
Koichiro, Kato, Kaori, Fukuzawa, Teruki, Honma   +2 more
core   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance. [PDF]

, 2021
A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir ...
Gensch, Alexander, Hirsch, Hans H., Martinez, Aurélien E, Asllanaj, E., Schweitzer, M., Tim Roloff, Søgaard, K.K., Leila Tamara Alexander, Stange, M, Leuzinger, K, Nickel, C.H., Martinez, AE, Battegay, M., Seth-Smith, Helena M. B., Gensch, A., Erblin Asllanaj, Marzolini, Catia, Tauriello, Gerardo, Osthoff, M, Stefano Bassetti, Michael Schweitzer, Bassetti, S., Schwede, T., Martin Siegemund, Battegay, M, Bassetti, Stefano, Nickel, Christian H, Schwede, Torsten, Bingisser, Roland, Søgaard, Kirstine K, Hirsch, H.H., Osthoff, Michael, Mari, Alfredo, Karoline Leuzinger, Pargger, H, Julia Bielicki, Seth-Smith, HMB, Pargger, H., Nickel, CH, Siegemund, M, Tauriello, G., Catia Marzolini, Alexander, LT, Bingisser, R, Søgaard, Kirstine K., Martinez, A.E., Battegay, Manuel, Helena M. B. Seth-Smith, Sendi, Parham, Michael Osthoff, Asllanaj, E, Marzolini, C., Aurélien E. Martinez, Marzolini, C, Bassetti, S, Egli, Adrian, Tauriello, G, Bielicki, J., Madlen Stange, Leuzinger, K., Siegemund, M., Pargger, Hans, Alexander, Leila Tamara, Roland Bingisser, Søgaard, KK, Christian H. Nickel, Adrian Egli, Parham Sendi, Mari, A., Stange, M., Egli, A., Mari, A, Alexander Gensch, Roloff, Tim, Gerardo Tauriello, Sendi, P, Asllanaj, Erblin, Seth-Smith, Helena M B, Schweitzer, Michael, Hirsch, Hans H, Osthoff, M., Hirsch, HH, Martinez, Aurélien E., Torsten Schwede, Bielicki, J, Schweitzer, M, Alfredo Mari, Egli, A, Leuzinger, Karoline, Kirstine K. Søgaard, Hans H. Hirsch, Roloff, T, Sendi, P., Bingisser, R., Stange, Madlen, Roloff, T., Manuel Battegay, Bielicki, Julia, Hans Pargger, Schwede, T, Gensch, A, Nickel, Christian H., Alexander, L.T., Siegemund, Martin   +103 more
core   +1 more source

In silico Screening of Cyanobacterial and Food Bioactive Compounds to Predict Potential Inhibitors of COVID-19 Main protease (Mpro), Papain-like protease (PLpro) and RNA-dependent RNA polymerase (RdRp)

, 2022
As novel corona virus (COVID-19) infections has spread throughout the world, world health organization (WHO) has announced COVID-19 as a pandemic infection.
Ankit, Patras, Brahmaiah, Pendyala
core   +1 more source

Intimate Interaction Between Nucleic Acid and Conjugated Polymers in Organic Electrochemical Transistors Enables Ultrasensitive Biomarker Detection

Advanced Materials, EarlyView.
The intimate interaction between negatively charged RNA molecules and conjugated polymers in organic electrochemical transistors (OECTs) in aqueous electrolytes is investigated. It demonstrates that RNA binding reduces the volumetric capacitance of the polymer channel, enabling the development of an ultrasensitive biosensing platform capable of ...
Hong Liu, Naixiang Wang, Anneng Yang, Jiajun Song, Li Li, Iain McCulloch, Helen Ka‐wai Law, Feng Yan   +7 more
wiley   +1 more source

RNA Editing with Viral RNA-Dependent RNA Polymerase

, 2022
RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR).
Shinzi Ogasawara (2426575), Ai Yamada (1730698), Ai Yamada, Shinzi Ogasawara   +3 more
core   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Exploring the Conformational Dynamics of RNA Dependent RNA Polymerase of SARS-CoV-2 in the Presence of Various Nucleotide Analogues

, 2020
RNA dependent RNA polymerase (RdRP) from positive stranded RNA viruses has always been a hot target for designing of new drugs as it is responsible for viral replication.
Uddhavesh, Sonavane, Rajendra, Joshi, Shruti, Koulgi, Vinod, Jani, Mallikarjunachari, Uppuladinne V N   +4 more
core   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp) [PDF]

International Journal of Molecular Sciences, 2012
Bovine Rhinitis B Virus (BRBV) is a picornavirus responsible for mild respiratory infection of cattle. It is probably the least characterized among the aphthoviruses. BRBV is the closest relative known to Foot and Mouth Disease virus (FMDV) with a ~43% identical polyprotein sequence and as much as 67% identical sequence for the RNA dependent RNA ...
Devendra K. Rai, Elizabeth Rieder
openaire   +2 more sources