Results 51 to 60 of about 57,300 (174)
, 2021 We analyzed molecular dynamic simulation using GROMACS to study the interaction between SARS-Cov-2 cryo-EM structure of RNA-dependent RNA polymerase (PDB ID: 6M71) and compound CHEMBL3120791 with 20ns simulation using NVIDIA GPU for high performance ...
Pavan, Gudipati
core +1 more source
, 2022 Remdesivir was the first antiviral drug that received emergency use authorization from the United States Food and Drug Administration and is now formally approved to treat COVID-19.
Sehr, Naseem-Khan +4 more
core +1 more source
, 2021 The unprecedented global health threat of SARS-CoV-2 has sparked a continued interest to discover novel anti-COVID-19 agents. To this end, we present here a computer-based protocol for identifying potential compounds targeting RNA-dependent RNA ...
Kin Israel , Notarte +7 more
core +1 more source
Interaction between Hantavirus Nucleocapsid Protein (N) and RNA-Dependent RNA Polymerase (RdRp) Mutants Reveals the Requirement of an N-RdRp Interaction for Viral RNA Synthesis [PDF]
Journal of Virology, 2014 ABSTRACT Viral ribonucleocapsids harboring the viral genomic RNA are used as the template for viral mRNA synthesis and replication of the viral genome by viral RNA-dependent RNA polymerase (RdRp). Here we show that hantavirus nucleocapsid protein (N protein) interacts with RdRp in virus-infected cells. We mapped the RdRp binding domain at the
Erdong Cheng, Zekun Wang, M. Mir
semanticscholar +3 more sources
Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase
, 2020 Zika virus (ZIKV) remains a potentially significant public health concern because it can cause teratogenic effects, such as microcephaly in newborns and neurological disease, like Guillain-Barré syndrome.
Bates, RW +8 more
core +1 more source
Identifying Therapeutic Compounds Targeting RNA-Dependent-RNA-Polymerase of Sars-Cov-2
, 2020 COVID-19 emerged as the biggest threat of this century for mankind and later it spread across the globe through human to human transmission. Scientists rushed to understand the structure and mechanism of the virus so that antiviral drugs or vaccines to ...
Muhammad, Roomi +2 more
core +1 more source
, 2020 The pandemic of SARS-CoV-2 has necessitated expedited research efforts towards finding potential antiviral targets and drug development measures. While new drug discovery is time consuming, drug repurposing has been a promising area for elaborate ...
Feroza, Begum, UPASANA, RAY
core +1 more source
, 2020 The COVID-19 pandemic speaks to the need for drugs that are not only effective but also remain so given the mutation rate of COVID-19. To this end, we describe a strategy to design potential drugs that target RNA-dependent RNA polymerase (RDRP), a common
Phil, bourne, zheng, zhao
core +1 more source
Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M. +8 more
core +1 more source
Spatial Perturbations within an RNA Promoter Specifically Recognized by a Viral RNA-Dependent RNA Polymerase (RdRp) Reveal That RdRp Can Adjust Its Promoter Binding Sites [PDF]
Journal of Virology, 1999 ABSTRACT RNA synthesis during viral replication requires specific recognition of RNA promoters by the viral RNA-dependent RNA polymerase (RdRp). Four nucleotides (−17, −14, −13, and −11) within the brome mosaic virus (BMV) subgenomic core promoter are required for RNA synthesis by the BMV RdRp (R. W. Siegel et al., Proc. Natl. Acad. Sci.
S. Stawicki, C. Kao
semanticscholar +3 more sources