Results 51 to 60 of about 4,271,507 (162)

Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA [PDF]

, 2003
The current model for influenza virus mRNA transcription involves the sequential interaction of the viral polymerase with the 5'- and 3'-ends of vRNA, with each RNA-protein interaction triggering a polymerase function necessary for cap-primed ...
Tiley, Laurence, Klumpp, Klaus, Digard, Paul, Lee, Michael T, M.-T. M. Lee   +4 more
core   +2 more sources

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening

Frontiers in Genetics, 2020
BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao, Dan Han, Lei Sun, Yanhong Wu, Yanhong Wu, Shuang Liu, Shuang Liu, Yaojiang Huang, Yaojiang Huang   +8 more
doaj   +1 more source

PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif [PDF]

, 2011
PAPD5 is one of the seven members of the family of noncanonical poly(A) polymerases in human cells. PAPD5 was shown to polyadenylate aberrant pre-ribosomal RNAs in vivo, similar to degradation-mediating polyadenylation by the noncanonical poly(A ...
Bilen, B., Keller, W., Mihaela Zavolan, Biter Bilen, Zavolan, M., Walter Keller, Rammelt, C., Christiane Rammelt   +7 more
core   +1 more source

Structure and Function of Caliciviral RNA Polymerases

Viruses, 2017
Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available.
Ji-Hye Lee, Mi Sook Chung, Kyung Hyun Kim   +2 more
doaj   +1 more source

A Single ssRNA Segment Encoding RdRp Is Sufficient for Replication, Infection, and Transmission of Ourmia-Like Virus in Fungi

Frontiers in Microbiology, 2020
Recently, an increasing number of ourmia-like viruses have been found in fungi; however, the features of these viruses remain unknown. Here, we report a novel ourmia-like virus isolated from Sclerotinia sclerotiorum. This virus, named S.
Qihua Wang, Qihua Wang, Fan Mu, Fan Mu, Jiatao Xie, Jiatao Xie, Jiasen Cheng, Jiasen Cheng, Yanping Fu, Daohong Jiang, Daohong Jiang   +10 more
doaj   +1 more source

Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly

mBio, 2018
Double-stranded RNA (dsRNA) viruses package several RNA-dependent RNA polymerases (RdRp) together with their dsRNA genome into an icosahedral protein capsid known as the polymerase complex.
Xiaoyu Sun, Serban L. Ilca, Juha T. Huiskonen, Minna M. Poranen   +3 more
doaj   +1 more source

RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases

Journal of Molecular Structure, 2022
Con la llegada de la pandemia de Covid-19, los agentes antivirales han recuperado el protagonismo en el ámbito de la medicina. De las diversas dianas farmacológicas involucradas en el manejo de las infecciones virales por ARN, la que domina casi todos los virus de ARN es la RdRp (ARN polimerasa dependiente de ARN). Las RdRp son proteínas que participan
Shelly Pathania, Ravindra K. Rawal, Pankaj Kumar Singh   +2 more
openaire   +2 more sources

Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication

Frontiers in Microbiology, 2018
Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or de novo RNA synthesis by RNA-dependent RNA polymerase (RdRp).
Ji-Hye Lee, Beom Seok Park, Intekhab Alam, Kang R. Han, Scott B. Biering, Soo J. Kim, Jayoung Choi, Jong H. Seok, Mi S. Chung, Ho M. Kim, Seungmin Hwang, Seungmin Hwang, Kyung H. Kim   +12 more
doaj   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter Assay

Cell Insight, 2022
Abstract COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose international public health threat and thus far, has resulted in greater than 5.6 million deaths worldwide.
Timsy Uppal, Kai Tuffo, Svetlana Khaiboullina, Sivani Reganti, Mark Pandori, Subhash C. Verma   +5 more
openaire   +3 more sources