Results 51 to 60 of about 34,592 (189)

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases [PDF]

Biology Open, 2019
ABSTRACT Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses.
Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski   +5 more
openaire   +5 more sources

Meta-analysis of honey bee neurogenomic response links deformed wing virus type A to precocious behavioral maturation [PDF]

, 2020
Crop pollination by the western honey bee Apis mellifera is vital to agriculture but threatened by alarmingly high levels of colony mortality, especially in Europe and North America.
Ahmed, Amy Cash, Bukhari, Syed Abbas, Hamilton, Adam R., Kevill, Jessica, Naeger, Nicholas L., Robinson, Gene E., Schroeder, Declan C., Traniello, Ian M.   +7 more
core   +1 more source

Blocking Zika virus vertical transmission. [PDF]

, 2018
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvir (SOF), an FDA-
Beltrão-Braga, Patricia CB, Corbett, Kevin D, Cugola, Fernanda R, Fernandes, Isabella R, Herai, Roberto H, Huang, Chun-Teng, Kolar, Matthew J, Macia, Angela, Mesci, Pinar, Momper, Jeremiah D, Montefusco, Sandro, Moore, Spencer M, Muotri, Alysson R, Pinto, Antonella, Rosenberg, Scott C, Russo, Fabiele B, Saghatelian, Alan, Sheets, Nicholas, Shiryaev, Sergey A, Shresta, Sujan, Siqueira-Neto, Jair L, Suarez, Nicole A, Tejwani, Leon, Terskikh, Alexey V   +23 more
core   +2 more sources

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response. [PDF]

, 2014
BACKGROUND: Infection with Leishmania parasites causes mainly cutaneous lesions at the site of the sand fly bite. Inflammatory metastatic forms have been reported with Leishmania species such as L. braziliensis, guyanensis and aethiopica. Little is known
Akopyants, N.S., Beverley, S.M., Desponds, C., Dobson, D.E., Fasel, N., Ghalib, H., Hailu, A., Lye, L.F., Ronet, C., Zangger, H.   +9 more
core   +6 more sources

Identification of potential inhibitors of Zika virus NS5 RNA-dependent RNA polymerase through virtual screening and molecular dynamic simulations

Saudi Pharmaceutical Journal, 2020
Zika virus (ZIKV) is one of the mosquito borne flavivirus with several outbreaks in past few years in tropical and subtropical regions. The non-structural proteins of flaviviruses are suitable active targets for inhibitory drugs due to their role in ...
Noreen, Roshan Ali, Syed Lal Badshah, Muhammad Faheem, Sumra Wajid Abbasi, Riaz Ullah, Ahmed Bari, Syed Babar Jamal, Hafiz Majid Mahmood, Adnan Haider, Sajjad Haider   +10 more
doaj   +1 more source

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.

PLoS Pathogens, 2021
Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations.
Robert M Cox, Julien Sourimant, Mugunthan Govindarajan, Michael G Natchus, Richard K Plemper   +4 more
doaj   +1 more source

RNA-DEPENDENT RNA POLYMERASE (RDRP) INHIBITOR DRUGS AGAINST SARS-COV-2: A MOLECULAR DOCKING STUDY

Ankara Universitesi Eczacilik Fakultesi Dergisi, 2022
Amaç: SARS-CoV-2 ile ilişkili viral pandemisi ilk olarak Aralık 2019'da Çin'in Wuhan kentinde bildirilmiştir. enfeksiyon gücünün yüksek olması nedeniyle, Dünya Sağlık Örgütü (DSÖ) 11 Mart 2020 tarihinde SARS-CoV-2’yi küresel pandemi olarak ilan etmiştir. Bu nedenle en önemli viral protein hedeflerinin belirlenmesi bir zorunluluk haline geldi.
GADO, Sarah, ALAGÖZ, Zeynep
openaire   +4 more sources

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening

Frontiers in Genetics, 2020
BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao, Dan Han, Lei Sun, Yanhong Wu, Yanhong Wu, Shuang Liu, Shuang Liu, Yaojiang Huang, Yaojiang Huang   +8 more
doaj   +1 more source