The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain [PDF]
, 2014 International audienceViral RNA-dependent RNA polymerases (RdRps) responsible for the replication of single-strand RNA virus genomes exert their function in the context of complex replication machineries. Within these replication complexes the polymerase
Canard, Bruno +5 more
core +7 more sources
RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro
Viruses, 2021 Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova +3 more
doaj +1 more source
PLoS Pathogens, 2023 LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses.
Zhongyuan Tan +11 more
doaj +1 more source
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
Signal Transduction and Targeted Therapy, 2022 The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have ...
Saisai Guo +18 more
doaj +1 more source
Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5. [PDF]
, 2020 During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles.
Goodbourn, S +6 more
core +3 more sources
Deep Sequencing Analysis of RNAs from Citrus Plants Grown in a Citrus Sudden Death-Affected Area Reveals Diverse Known and Putative Novel Viruses. [PDF]
, 2017 Citrus sudden death (CSD) has caused the death of approximately four million orange trees in a very important citrus region in Brazil. Although its etiology is still not completely clear, symptoms and distribution of affected plants indicate a viral ...
Coletta-Filho, Helvecio D +7 more
core +11 more sources
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs. [PDF]
PLoS ONE, 2017 Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted for antiviral drug development.
Ona Barauskas +10 more
doaj +1 more source
Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]
PLoS Pathogens, 2016 During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier +5 more
doaj +1 more source
Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
Molecules, 2020 The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism.
Francesca Picarazzi +4 more
doaj +1 more source
Communications Biology, 2022 Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication can ...
Eleni-Anna Loundras +6 more
doaj +1 more source