Results 31 to 40 of about 26,028 (198)

Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against SARS-CoV2 infection [PDF]

All Life, 2020
Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Charles Allen, Sterling Arjona, Maryline Santerre, Bassel E Sawaya   +3 more
openaire   +2 more sources

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs. [PDF]

PLoS ONE, 2017
Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted for antiviral drug development.
Ona Barauskas, Weimei Xing, Esmeralda Aguayo, Madeleine Willkom, Annapurna Sapre, Michael Clarke, Gabriel Birkus, Brian E Schultz, Roman Sakowicz, HyockJoo Kwon, Joy Y Feng   +10 more
doaj   +1 more source

LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities.

PLoS Pathogens, 2023
LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses.
Zhongyuan Tan, Jiqin Wu, Li Huang, Ting Wang, Zhenhua Zheng, Jianhui Zhang, Xianliang Ke, Yuan Zhang, Yan Liu, Hanzhong Wang, Jianping Tao, Peng Gong   +11 more
doaj   +1 more source

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Signal Transduction and Targeted Therapy, 2022
The coronavirus disease 2019 (COVID-19) pandemic has devastated global health. Identifying key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have ...
Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen   +18 more
doaj   +1 more source

Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]

PLoS Pathogens, 2016
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier, Outi L Lyytinen, Yusong R Guo, Yukimatsu Toh, Minna M Poranen, Yizhi J Tao   +5 more
doaj   +1 more source

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases [PDF]

Biology Open, 2019
ABSTRACT Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses.
Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski   +5 more
openaire   +5 more sources

Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]

, 2011
The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin, Richard M. Elliott, Li, Ping, Ping Li, Elliott, Richard M., Benjamin Brennan   +5 more
core   +1 more source

RNA-dependent RNA polymerases in the black-legged tick produce Argonaute-dependent small RNAs and regulate genes [PDF]

, 2021
Small regulatory RNAs (sRNAs) are involved in anti-viral defense and gene regulation. Although RNA-dependent RNA Polymerases (RdRPs) are known to produce sRNA in nematodes, plants and fungi, whether they play roles in sRNA biogenesis in other animals ...
Okamura, Katsutomo, Feng, Canran, 26389, Iida, Junko, Lim, Mandy Yu Theng, 26384, Torimaru, Kyosuke, 26386, 26385, 26388, Tanaka, Tetsuya, 26387, Tsuji, Kosuke, Chak, Li-Ling, 26391, 26390   +15 more
core   +1 more source

Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication

Communications Biology, 2022
Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication can ...
Eleni-Anna Loundras, James Streetley, Morgan R. Herod, Rebecca Thompson, Mark Harris, David Bhella, Nicola J. Stonehouse   +6 more
doaj   +1 more source