Conformational analysis between 6M71 (SARS COV2 RNA-dependent RNA polymerase) and CHEMBL3120791 using GROMACS Molecular Dynamic simulation. [PDF]
, 2021 We analyzed molecular dynamic simulation using GROMACS to study the interaction between SARS-Cov-2 cryo-EM structure of RNA-dependent RNA polymerase (PDB ID: 6M71) and compound CHEMBL3120791 with 20ns simulation using NVIDIA GPU for high performance ...
Pavan, Gudipati
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Cell Reports, 2017 Summary: RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the ...
David Dulin +9 more
doaj +1 more source
Plant-Derived Natural Polyphenols as Potential Antiviral Drugs Against SARS-CoV-2 via RNA‐dependent RNA Polymerase (RdRp) Inhibition: An In-Silico Analysis [PDF]
, 2020 The sudden outburst of Coronavirus disease (COVID-19) has left the entire world to a standstill. COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Satyam, Singh +2 more
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RNA-dependent RNA polymerases in the black-legged tick produce Argonaute-dependent small RNAs and regulate genes [PDF]
, 2021 Small regulatory RNAs (sRNAs) are involved in anti-viral defense and gene regulation. Although RNA-dependent RNA Polymerases (RdRPs) are known to produce sRNA in nematodes, plants and fungi, whether they play roles in sRNA biogenesis in other animals ...
Okamura, Katsutomo +15 more
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Regulation of viral RNA-dependent RNA polymerases by phosphorylation
Frontiers in Virology, 2023 RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which is essential for transcription and replication of their genome since host cells lack equivalent enzymes.
Camille Duflos, Thomas Michiels
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RNA-dependent RNA Polymerase Assay for Hepatitis E Virus
Bio-Protocol, 2017 RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair +3 more
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STAR Protocols, 2022 Summary: Nucleotide/nucleoside analogs (NAs) are important compounds used in antiviral drug development. To understand the action mode of NA drugs, we present an enzymology protocol to initially evaluate the intervention mechanism of the NTP forms of NAs
Qiaojie Liu, Jiqin Wu, Peng Gong
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Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages [PDF]
, 2015 Date of Acceptance: 02/01/2015Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Jones, John T. +60 more
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RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +5 more
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A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T +3 more
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