Results 31 to 40 of about 3,624,287 (199)
Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus. [PDF]
PLoS Pathogens, 2016 During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral capsid.
Aaron M Collier +5 more
doaj +1 more source
Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases [PDF]
Biology Open, 2019 ABSTRACT Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses.
Federica Riccio +5 more
openaire +5 more sources
Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]
, 2012 tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena +3 more
core +1 more source
Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
Molecules, 2020 The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism.
Francesca Picarazzi +4 more
doaj +1 more source
Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase [PDF]
, 2011 The viral RNA-dependent RNA polymerase (RdRp; L protein) of Rift Valley fever virus (RVFV; family Bunyaviridae) is a 238 kDa protein that is crucial for the life cycle of the virus, as it catalyses both transcription of viral mRNAs and replication of the
Brennan, Benjamin +5 more
core +1 more source
Communications Biology, 2022 Loundras et al. report on the fibril components of the RNA-dependent RNA polymerase RdRp from foot-and-mouth disease virus. They demonstrate that higher-order fibril-based interactions create multiple complex structures within which RNA replication can ...
Eleni-Anna Loundras +6 more
doaj +1 more source
Cell Reports, 2017 Summary: RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the ...
David Dulin +9 more
doaj +1 more source
STAR Protocols, 2022 Summary: Nucleotide/nucleoside analogs (NAs) are important compounds used in antiviral drug development. To understand the action mode of NA drugs, we present an enzymology protocol to initially evaluate the intervention mechanism of the NTP forms of NAs
Qiaojie Liu, Jiqin Wu, Peng Gong
doaj +1 more source
RNA-dependent RNA Polymerase Assay for Hepatitis E Virus
Bio-Protocol, 2017 RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair +3 more
doaj +1 more source
Regulation of viral RNA-dependent RNA polymerases by phosphorylation
Frontiers in Virology, 2023 RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which is essential for transcription and replication of their genome since host cells lack equivalent enzymes.
Camille Duflos, Thomas Michiels
doaj +1 more source