Results 41 to 50 of about 54,553 (112)

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

bioRxiv, 2020
The pandemic of Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 has become a global crisis. The replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp), a direct target of the antiviral drug, Remdesivir.
W. Yin, C. Mao, X. Luan, D. Shen, Q. Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, He-wei Jiang, S. Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu   +21 more
semanticscholar   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Journal of Biological Chemistry, 2020
Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2).
Calvin J. Gordon, E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +4 more
semanticscholar   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir–ritonavir in patients with COVID‐19

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2390-2402, July 2026.
Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman, Laura Buggiotti, Li‐An K. Brown, Jose A. Guerra‐Assuncao, Japhette E. Kembou‐Ringert, Wen Y. Mak, Judith Breuer, David M. Lowe, Joseph F. Standing, FLARE Investigators   +9 more
wiley   +1 more source

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science, 2020
A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
Wanchao Yin, Wanchao Yin, C. Mao, Xiaodong Luan, Xiaodong Luan, D. Shen, Qingya Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, He-wei Jiang, Sheng-ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Shuyang Zhang, Yan Zhang, H. E. Xu   +24 more
semanticscholar   +1 more source

Coronavirus M Protein Hijacks Toll‐Interacting Protein (TOLLIP) to Suppress NF‐κB Signaling and Promote Immune Evasion

MedComm, Volume 7, Issue 7, July 2026.
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang, Lu Kang, Yu Zhong, Songjun Shao, Senren Xue, Changliang Liu, Xiaoqi Zheng, Jing‐Wen Lin, Yu Chen, Fengming Luo, Huajing Wan   +10 more
wiley   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero, Ileana Vigentini, Gabriella De Lorenzis, Silvia Laura Toffolatti   +12 more
wiley   +1 more source

Cucumber green mottle mosaic virus: A persistent seed‐borne threat to cucurbits

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Cucumber green mottle mosaic virus (CGMMV) is a highly stable, seed‐borne tobamovirus that threatens global cucurbit production. Its efficient mechanical and seed transmission, long‐term environmental persistence, and the spread of Clade II CGMMV isolates drive its rapid dissemination and cause severe yield losses.
Esperanza Gea‐Caballero, Miguel A. Aranda   +1 more
wiley   +1 more source

Potato leafroll virus: A re‐emerging threat to sustainable potato production

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Potato leafroll virus (PLRV) is a positive‐strand RNA virus. Virus particles of PLRV are isometric, 24 nm in diameter. PLRV is the causal agent of leafroll disease in potato (Solanum tuberosum L.) which causes significant losses in yield and quality of potato tubers.
Eugene V. Ryabov, Andrew Love, Lesley Torrance   +2 more
wiley   +1 more source