Results 41 to 50 of about 26,028 (198)

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages [PDF]

, 2015
Date of Acceptance: 02/01/2015Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Jones, John T., Murray E Selkirk, John T Jones, Goldstein, R, Phillip M. Schiffer (691095), Bob Goldstein, Miska, E A, Taylor, Mark J., Eric A. Miska (41828), Blaxter, Mark L., Murray E. Selkirk (202480), Miska, Eric A., Christopher Kraus (691096), John T. Jones (207247), Fast, Naomi M., Sarkies, P, Peter Sarkies (691090), Alex Ardila-Garcia, Ben Hanelt (107535), Blok, V, Schiffer, Phillip M., Georgios Koutsovoulos (556628), Hanelt, Ben, Georgios Koutsovoulos, Boothby, Thomas, Ben Hanelt, Naomi M. Fast (691094), Koutsovoulos, Georgios, Mark J Taylor, Bob Goldstein (265221), Selkirk, Murray E., Phillip M Schiffer, Ardila-Garcia, Alex, Eric A Miska, Alex Ardila-Garcia (691093), Thomas Boothby, Hanelt, B, Mark J. Taylor (118298), Thomas Boothby (691092), Mark L. Blaxter (115482), Selkirk, M E, Vivian Blok (691091), Blok, Vivian, Naomi M Fast, Taylor, Mark; id_orcid, Kraus, C, Schiffer, P M, Sarkies, Peter, Jones, J T, Goldstein, Bob, Fast, N M, Christopher Kraus, Koutsovoulos, G, Taylor, M J, Ardila-Garcia, A, Mark L Blaxter, Kraus, Christopher, Blaxter, M L, Boothby, T, Peter Sarkies, Vivian Blok   +60 more
core   +1 more source

Conformational analysis between 6M71 (SARS COV2 RNA-dependent RNA polymerase) and CHEMBL3120791 using GROMACS Molecular Dynamic simulation.

, 2021
We analyzed molecular dynamic simulation using GROMACS to study the interaction between SARS-Cov-2 cryo-EM structure of RNA-dependent RNA polymerase (PDB ID: 6M71) and compound CHEMBL3120791 with 20ns simulation using NVIDIA GPU for high performance ...
Pavan, Gudipati
core   +1 more source

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge

Molecules, 2020
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism.
Francesca Picarazzi, Ilaria Vicenti, Francesco Saladini, Maurizio Zazzi, Mattia Mori   +4 more
doaj   +1 more source

Regulation of viral RNA-dependent RNA polymerases by phosphorylation

Frontiers in Virology, 2023
RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which is essential for transcription and replication of their genome since host cells lack equivalent enzymes.
Camille Duflos, Thomas Michiels
doaj   +1 more source

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

Cell Reports, 2017
Summary: RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the ...
David Dulin, Jamie J. Arnold, Theo van Laar, Hyung-Suk Oh, Cheri Lee, Angela L. Perkins, Daniel A. Harki, Martin Depken, Craig E. Cameron, Nynke H. Dekker   +9 more
doaj   +1 more source

Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases

STAR Protocols, 2022
Summary: Nucleotide/nucleoside analogs (NAs) are important compounds used in antiviral drug development. To understand the action mode of NA drugs, we present an enzymology protocol to initially evaluate the intervention mechanism of the NTP forms of NAs
Qiaojie Liu, Jiqin Wu, Peng Gong
doaj   +1 more source

Impact of Remdesivir Incorporation Along the Primer Strand on SARS-CoV-2 RNA-dependent RNA polymerase

, 2022
Remdesivir was the first antiviral drug that received emergency use authorization from the United States Food and Drug Administration and is now formally approved to treat COVID-19.
Sehr, Naseem-Khan, Madison B., Berger, Emmett M., Leddin, G. Andrés, Cisneros, Yazdan , Maghsoud   +4 more
core   +1 more source

RNA-dependent RNA Polymerase Assay for Hepatitis E Virus

Bio-Protocol, 2017
RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair, Saumya Anang, Akriti Srivastava, Milan Surjit   +3 more
doaj   +1 more source

Combinatorial library screening of quinadoline B derivatives against SARS-CoV-2 RNA-dependent RNA polymerase

, 2021
The unprecedented global health threat of SARS-CoV-2 has sparked a continued interest to discover novel anti-COVID-19 agents. To this end, we present here a computer-based protocol for identifying potential compounds targeting RNA-dependent RNA ...
Kin Israel , Notarte, Mark Tristan , Quimque, simone, brogi, Vincenzo, Calderone, Jeremiah Gabriel, Africa, Allan Patrick , Macabeo, Jenina Beatriz, Hernandez, Sophia Morgan, Tan   +7 more
core   +1 more source

Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase

, 2020
Zika virus (ZIKV) remains a potentially significant public health concern because it can cause teratogenic effects, such as microcephaly in newborns and neurological disease, like Guillain-Barré syndrome.
Bates, RW, Tan, ST, Lescar, J, Santhanakrishnan, S, Vasudevan, SG, Gharbi-Ayachi, A, Chan, KWK, Sahili, AE, Wong, YH   +8 more
core   +1 more source