Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods. [PDF]
Biophys Chem, 2021 Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. Since developing antiviral drugs is a time-consuming process, the most effective approach is to evaluate the approved and under investigation drugs using in silico methods. Among the different targets within the virus structure, as a vital component in the life
Poustforoosh A +5 more
europepmc +3 more sources
Molecular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus. [PDF]
Bioinformation, 2021 It is of interest to document the moelcular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus. Hence, we report the binding features of rutin, Luteolin, Salvianolic acid A, Rosmarinic acid and p-Coumaric acid with the target protein SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp)
Selvaraj J +8 more
europepmc +4 more sources
Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain
BioMedInformatics, 2023 We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species.
Aparna S. Gana, James N. Baraniuk
doaj +2 more sources
Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp). [PDF]
Molecules, 2022 Karthic A +7 more
europepmc +2 more sources
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
Current Medicinal Chemistry, 2022 Background: SARS-CoV-2, which emerged in Wuhan, China, is a new global threat that has killed millions of people and continues to do so. This pandemic has not only threatened human life but has also triggered economic downturns across the world. Researchers have made significant strides in discovering molecular insights into SARSCoV- 2 pathogenesis ...
Shabana Bibi +4 more
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RNA-Dependent RNA Polymerase of the Second Human Pegivirus Exhibits a High-Fidelity Feature
Microbiology Spectrum, 2022 The virus-encoded RNA-dependent RNA polymerase (RdRp) is responsible for viral replication, and its fidelity is closely related to viral diversity, pathogenesis, virulence, and fitness.
Shuyi Chen +10 more
doaj +1 more source
Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against SARS-CoV2 infection [PDF]
All Life, 2020 Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Charles Allen +3 more
openaire +2 more sources
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
Viruses, 2021 SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding ...
Milan Dejmek +9 more
doaj +1 more source
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Nature Communications, 2021 Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and is used as a drug to treat COVID19 patients. Here, the authors provide insights into the mechanism of remdesivir-induced RdRp stalling by determining ...
Goran Kokic +9 more
doaj +1 more source
Hepatitis C Virus (HCV) NS5A Binds RNA-dependent RNA Polymerase (RdRP) NS5B and Modulates RNA-dependent RNA Polymerase Activity [PDF]
Journal of Biological Chemistry, 2002 Hepatitis C virus (HCV) NS5B is RNA-dependent RNA polymerase (RdRP), the essential catalytic enzyme for HCV replication. Recently, NS5A has been reported to be important for the establishment of HCV replication in vitro by the adaptive mutations, although its role in viral replication remains uncertain.
Yukihiro, Shirota +6 more
openaire +2 more sources