Results 11 to 20 of about 34,592 (189)

RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19. [PDF]

Cancer Sci, 2020
AbstractA recent outbreak of coronavirus disease (COVID‐19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID‐19 is keenly anticipated.
Machitani M, Yasukawa M, Nakashima J, Furuichi Y, Masutomi K.   +4 more
europepmc   +6 more sources

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2. [PDF]

Comput Biol Med, 2021
The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp, however its mechanism of action remains elusive. This study aims to find out the binding dynamics of active Remdesivir-triphosphate (RDV-TP) to RdRp by means of molecular dynamics (MD)
Arba M, Wahyudi ST, Brunt DJ, Paradis N, Wu C.   +4 more
europepmc   +5 more sources

Emerging genetic diversity of SARS-CoV-2 RNA dependent RNA polymerase (RdRp) alters its B-cell epitopes. [PDF]

Biologicals, 2022
The RNA dependent RNA polymerase (RdRp) plays crucial role in virus life cycle by replicating the viral genome. The SARS-CoV-2 is an RNA virus that rapidly spread worldwide and acquired mutations. This study was carried out to identify mutations in RdRp as the SARS-CoV-2 spread in India.
Kumar S, Kumari K, Azad GK.
europepmc   +5 more sources

A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp). [PDF]

J Biomol Struct Dyn, 2022
The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern. The efforts of the scientific community are pointed towards the identification of promptly available therapeutic options.
Ribaudo G, Ongaro A, Oselladore E, Zagotto G, Memo M, Gianoncelli A.   +5 more
europepmc   +4 more sources

Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2. [PDF]

Mol Divers, 2022
Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon after this, it was discarded. Similarly, known antiviral compounds were also proposed and investigated
Mishra A, Rathore AS.
europepmc   +4 more sources

Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening. [PDF]

Struct Chem, 2023
Abstract The SARS-CoV-2 coronavirus is responsible for the COVID-19 outbreak, which overwhelmed millions of people worldwide; hence, there is an urgency to identify appropriate antiviral drugs. This study focuses on screening compounds that inhibit RNA-dependent RNA-polymerase (RdRp) essential for RNA synthesis required for replication of positive ...
Jade D, Alzahrani A, Critchley W, Ponnambalam S, Harrison MA.   +4 more
europepmc   +3 more sources

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain. [PDF]

Chem Phys Lett, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral drugs. In this study, a chemical library (n = 300) was screened against the nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain.
Pitsillou E, Liang J, Yu Meng Huang H, Hung A, Karagiannis TC.   +4 more
europepmc   +3 more sources

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity. [PDF]

Comput Struct Biotechnol J, 2022
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has posed a serious threat to global health and the economy for over two years, prompting the need for development of antiviral inhibitors. Due to its vital role in viral replication, RNA-dependent RNA polymerase (RdRp) is a promising therapeutic target.
Uengwetwanit T, Chutiwitoonchai N, Wichapong K, Karoonuthaisiri N.   +3 more
europepmc   +6 more sources

Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication [PDF]

Journal of Biological Chemistry, 2016
Dengue virus, an ∼10.7-kb positive-sense RNA virus, is the most common arthropod-communicated pathogen in the world. Despite dengue's clear epidemiological importance, mechanisms for its replication remain elusive. Here, we probed the entire dengue genome for interactions with viral RNA-dependent RNA polymerase (RdRp), and we identified the dominant ...
Kenneth, Hodge, Chairat, Tunghirun, Maliwan, Kamkaew, Thawornchai, Limjindaporn, Pa-Thai, Yenchitsomanus, Sarin, Chimnaronk   +5 more
openaire   +4 more sources

Licoflavone B Suppresses Influenza A Virus by Targeting the Viral RNA-Dependent RNA Polymerase (RdRp). [PDF]

Viruses
Influenza A virus pandemics pose a persistent global health threat, and emerging antiviral resistance underscores the critical importance of developing novel broad-spectrum therapeutic agents. Building on licorice’s (Glycyrrhiza spp.) historical use in traditional Chinese medicine for respiratory infections—as documented in the Chinese Guidelines for ...
Fan P, Lv P, Zhang S, Zhu Z, Qian K, Han J, Cui Y, Feng Y, Li Z, Qiang L, Dong Y, Fang T, Jiang T, Yu C, Chi X.   +14 more
europepmc   +3 more sources