Results 11 to 20 of about 4,271,507 (162)

A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) [PDF]

Journal of Biomolecular Structure and Dynamics, 2020
The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern. The efforts of the scientific community are pointed towards the identification of promptly available therapeutic options.
Ribaudo, Giovanni, Ongaro, Alberto, Oselladore, Erika, Zagotto, Giuseppe, Memo, Maurizio, Gianoncelli, Alessandra   +5 more
openaire   +3 more sources

Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach [PDF]

Annals of Antivirals and Antiretrovirals, 2018
Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina. The docking studies reveal that thiolutin interacted with Hepatitis C Virus RNA Dependent RNA Polymerase through hydrogen bonding as well as hydrophobic interactions.
Asma Munawar, Syed Bilal Hussain, Muhammad Imran Qadir   +2 more
openaire   +2 more sources

RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2 [PDF]

Journal of Biomolecular Structure and Dynamics, 2021
RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Mishra, Avinash, Rathore, Anurag S.
openaire   +3 more sources

Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

Current Medicinal Chemistry, 2022
Background: SARS-CoV-2, which emerged in Wuhan, China, is a new global threat that has killed millions of people and continues to do so. This pandemic has not only threatened human life but has also triggered economic downturns across the world. Researchers have made significant strides in discovering molecular insights into SARSCoV- 2 pathogenesis ...
Shabana Bibi, Mohammad Mehedi Hasan, Yuan-Bing Wang, Stavros P. Papadakos, Hong Yu   +4 more
  +6 more sources

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review

Medicinal Chemistry Research, 2022
Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Daniela Regina Buch Leite, Karen Mary Mantovani, Solange Pereira Cordeiro, Filipe Barros Maia, Fernando Cesar Martins Betim, Elisiane de Bona Sartor, Deise Prehs Montrucchio, Josiane de Fátima Gaspari Dias, Obdulio Gomes Miguel, Marilis Dallarmi Miguel   +9 more
openaire   +2 more sources

Hepatitis C Virus (HCV) NS5A Binds RNA-dependent RNA Polymerase (RdRP) NS5B and Modulates RNA-dependent RNA Polymerase Activity [PDF]

Journal of Biological Chemistry, 2002
Hepatitis C virus (HCV) NS5B is RNA-dependent RNA polymerase (RdRP), the essential catalytic enzyme for HCV replication. Recently, NS5A has been reported to be important for the establishment of HCV replication in vitro by the adaptive mutations, although its role in viral replication remains uncertain.
Yukihiro, Shirota, Hong, Luo, Weiping, Qin, Shuichi, Kaneko, Tatsuya, Yamashita, Kenichi, Kobayashi, Seishi, Murakami   +6 more
openaire   +2 more sources

Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against SARS-CoV2 infection [PDF]

All Life, 2020
Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Charles Allen, Sterling Arjona, Maryline Santerre, Bassel E Sawaya   +3 more
openaire   +2 more sources

Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase [PDF]

, 2020
Zika virus (ZIKV) remains a potentially significant public health concern because it can cause teratogenic effects, such as microcephaly in newborns and neurological disease, like Guillain-Barré syndrome.
Bates, RW, Tan, ST, Lescar, J, Santhanakrishnan, S, Vasudevan, SG, Gharbi-Ayachi, A, Chan, KWK, Sahili, AE, Wong, YH   +8 more
core   +1 more source

Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses

RSC Medicinal Chemistry, 2021
This review summarizes the latest advances in the RNA-dependent RNA polymerase (RdRp) inhibitors targeting various viruses.
Rahul Kumar, Sahil Mishra, null Shreya, Sushil K. Maurya   +3 more
openaire   +3 more sources

Impact of Remdesivir Incorporation Along the Primer Strand on SARS-CoV-2 RNA-dependent RNA polymerase [PDF]

, 2022
Remdesivir was the first antiviral drug that received emergency use authorization from the United States Food and Drug Administration and is now formally approved to treat COVID-19.
Sehr, Naseem-Khan, Madison B., Berger, Emmett M., Leddin, G. Andrés, Cisneros, Yazdan , Maghsoud   +4 more
core   +2 more sources