RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2 [PDF]
Journal of Biomolecular Structure and Dynamics, 2022 RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Avinash Mishra, Anurag S Rathore
exaly +6 more sources
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic [PDF]
European Journal of Medicinal Chemistry, 2021 The widespread nature of several viruses is greatly credited to their rapidly altering RNA genomes that enable the infection to persist despite challenges presented by host cells. Within the RNA genome of infections is RNA-dependent RNA polymerase (RdRp), which is an essential enzyme that helps in RNA synthesis by catalysing the RNA template-dependent ...
Lei Tian +2 more
exaly +4 more sources
RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19 [PDF]
Cancer Science, 2020 AbstractA recent outbreak of coronavirus disease (COVID‐19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID‐19 is keenly anticipated.
Mitsuhiro Machitani +2 more
exaly +5 more sources
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2 [PDF]
Computers in Biology and Medicine, 2021 The RNA-dependent RNA polymerase (RdRp) is a key enzyme which regulates the viral replication of SARS-CoV-2. Remdesivir (RDV) is clinically used drug which targets RdRp, however its mechanism of action remains elusive. This study aims to find out the binding dynamics of active Remdesivir-triphosphate (RDV-TP) to RdRp by means of molecular dynamics (MD)
Muhammad Arba +2 more
exaly +4 more sources
RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review. [PDF]
Med Chem Res, 2022 Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Leite DRB +9 more
europepmc +3 more sources
Emerging genetic diversity of SARS-CoV-2 RNA dependent RNA polymerase (RdRp) alters its B-cell epitopes [PDF]
Biologicals, 2022 Gajendra Kumar Azad
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Thiolutin Derivatives as inhibitor of RNA-Dependent RNA Polymerase (RdRP) of Hepatitis C Virus: An In-silico Approach [PDF]
Annals of Antivirals and Antiretrovirals, 2018 Docking study of few Thiolutin derivatives, which originally act as Hepatitis C Virus RNA Dependent RNA Polymerase (RdRP) inhibitor, was performed by using AutoDock Vina.
Asma Munawar +2 more
core +2 more sources
Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter Assay [PDF]
Cell Insight, 2022 Abstract COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose international public health threat and thus far, has resulted in greater than 5.6 million deaths worldwide.
Uppal T +5 more
europepmc +5 more sources
Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses. [PDF]
RSC Med Chem, 2021 This review summarizes the latest advances in the RNA-dependent RNA polymerase (RdRp) inhibitors targeting various viruses.
Kumar R, Mishra S, Shreya, Maurya SK.
europepmc +4 more sources
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective. [PDF]
J Biomol Struct Dyn, 2021 New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the ...
Elfiky AA.
europepmc +4 more sources