SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study [PDF]
Heliyon, 2020 The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad +4 more
doaj +7 more sources
Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) [PDF]
Molecules, 2021 An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu +10 more
doaj +5 more sources
A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp). [PDF]
J Biomol Struct Dyn, 2022 The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a worldwide outbreak of coronavirus disease 19 (COVID-19), which rapidly evolved as a global concern.
Ribaudo G +5 more
europepmc +5 more sources
RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases [PDF]
Journal of Molecular Structure, 2022 With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in the arena of medicine. Out of the various drug targets involved in managing RNA-viral infections, the one that dominates almost all RNA viruses is RdRp (RNA ...
Shelly Pathania +2 more
exaly +4 more sources
Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain
BioMedInformatics, 2023 We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species.
Aparna S. Gana, James N. Baraniuk
doaj +4 more sources
Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2 [PDF]
European Journal of Medicinal Chemistry, 2023 The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of the key enzymes that control viral replication. RdRp is an attractive and promising therapeutic target for the treatment of SARS-CoV-2 disease.
Mohamed S Bekheit +2 more
exaly +4 more sources
Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening. [PDF]
Struct Chem, 2023 The SARS-CoV-2 coronavirus is responsible for the COVID-19 outbreak, which overwhelmed millions of people worldwide; hence, there is an urgency to identify appropriate antiviral drugs.
Jade D +4 more
europepmc +2 more sources
FEBS Open Bio, 2014 Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication.
Kunduri Govind +2 more
doaj +3 more sources
Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
doaj +2 more sources
Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp) [PDF]
Molecules, 2022 Veerbhan Kesarwani +2 more
exaly +2 more sources