SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study [PDF]
Heliyon, 2020 The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad +4 more
doaj +7 more sources
Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) [PDF]
Molecules, 2021 An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu +10 more
doaj +5 more sources
Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2. [PDF]
Eur J Med Chem, 2023 The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of the key enzymes that control viral replication. RdRp is an attractive and promising therapeutic target for the treatment of SARS-CoV-2 disease.
Bekheit MS, Panda SS, Girgis AS.
europepmc +5 more sources
RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2. [PDF]
J Biomol Struct Dyn, 2022 RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the ...
Mishra A, Rathore AS.
europepmc +7 more sources
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic. [PDF]
Eur J Med Chem, 2021 The widespread nature of several viruses is greatly credited to their rapidly altering RNA genomes that enable the infection to persist despite challenges presented by host cells. Within the RNA genome of infections is RNA-dependent RNA polymerase (RdRp), which is an essential enzyme that helps in RNA synthesis by catalysing the RNA template-dependent ...
Tian L +11 more
europepmc +5 more sources
RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review. [PDF]
Med Chem Res, 2022 Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds.
Leite DRB +9 more
europepmc +3 more sources
Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2. [PDF]
Viruses, 2023 COVID-19, a disease caused by SARS-CoV-2, has caused a huge loss of human life, and the number of deaths is still continuing. Despite the lack of repurposed drugs and vaccines, the search for potential small molecules to inhibit SARS-CoV-2 is in demand.
Bakheit AH +5 more
europepmc +4 more sources
Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter Assay [PDF]
Cell Insight, 2022 AbstractCOVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus-2) continues to pose international public health threat and thus far, has resulted in greater than 5.6 million deaths worldwide. Vaccines are critical tools to limit COVID-19 spread, but antiviral drug development is an ongoing global ...
Uppal T +5 more
europepmc +5 more sources
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective. [PDF]
J Biomol Struct Dyn, 2021 New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against different viral infections. In this work, molecular modeling, docking, and dynamics simulations are used to build a model for the ...
Elfiky AA.
europepmc +4 more sources
Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses. [PDF]
RSC Med Chem, 2021 This review summarizes the latest advances in the RNA-dependent RNA polymerase (RdRp) inhibitors targeting various viruses.
Kumar R, Mishra S, Shreya, Maurya SK.
europepmc +4 more sources