Results 101 to 110 of about 57,300 (174)
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.Tautomerization‐assisted oxidation of molnupiravir by superoxide (O2•−) in aprotic DMF. The thermodynamically favored oxime tautomer of the N4‐hydroxycytosine moiety forms a prereactive complex (PRC) with O2•− through hydrogen‐bonding interactions.
Tatsushi Nakayama, Kaisei Hara
wiley +1 more source
The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic. [PDF]
Viruses, 2023 Comunale BA +5 more
europepmc +1 more source
Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
Favipiravir as RNA Polymerase Dependent (Rdrp) in COVID-19
, 2021 Coronavirus disease 2019 or Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a new virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease became a pandemic and is being discussed around world because it has
Suharto, Fadel Fikri
core
, 2023 Dysregulation of mRNA processing results in diseases such as cancer. Although RNA editing technologies attract attention as gene therapy for repairing aberrant mRNA, substantial sequence defects arising from mis-splicing cannot be corrected by existing ...
Sae Ebashi, Shinzi Ogasawara
core +1 more source
Antiviral Research, 2019 The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the ...
Ariane J. Brown +9 more
semanticscholar +1 more source
Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.Abstract Snakehead rhabdovirus (SHRV) is a novirhabdovirus associated with disease outbreaks in warm‐water fish in Southeast Asia, including striped snakehead (Channa striata), but recent information on SHRV in Thai snakehead aquaculture remains limited.
Kitipong Angsujinda +4 more
wiley +1 more source
The Pathogenesis‐Related Protein 4b Induced by Rice Stripe Virus Enhances Host's Antiviral Defence
Molecular Plant Pathology, Volume 27, Issue 6, June 2026.OsPR4b is induced by RSV to inhibit viral infection via regulating RNA metabolism and cell wall reinforcement, while its knockdown modulates NAC/MYB/ERF/WRKY family genes and enhances viral accumulation. ABSTRACT Rice stripe virus (RSV) causes rice stripe disease, which poses a serious threat to rice production.
Binhao Gao +7 more
wiley +1 more source
Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
core +1 more source
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Viruses, 2019 Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov +3 more
semanticscholar +1 more source