Results 121 to 130 of about 3,624,287 (199)

Sequence Analysis of Hot Spot Regions of Spike and RNA-dependent-RNA polymerase (RdRp) Genes of SARS-CoV-2 in Kerman, Iran. [PDF]

Mediterr J Hematol Infect Dis, 2023
Arefinia N, Yaghobi R, Ramezani A, Sarvari J.   +3 more
europepmc   +2 more sources

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, Volume 13, Issue 45, 13 August 2026.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

Insight into Influenza: A Virus Cap-Snatching

Viruses, 2018
The influenza A virus (IAV) genome consists of eight single-stranded RNA segments. Each segment is associated with a protein complex, with the 3′ and 5′ ends bound to the RNA-dependent RNA polymerase (RdRp) and the remainder associated with ...
Corey De Vlugt, Dorota Sikora, Martin Pelchat   +2 more
doaj   +1 more source

Genomic and Epidemiological Characterization of DENV‐1 and DENV‐2 Co‐Circulation During the 2023–2024 Dengue Epidemic in Espírito Santo, Brazil

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT In 2023 and 2024, Espírito Santo state, Brazil, experienced its largest dengue epidemic in 30 years, with record numbers of cases and deaths. This study aimed to characterize confirmed dengue cases and the dengue virus (DENV) during the epidemic and pre‐epidemic periods.
Nicolli Ribeiro de Jesus, Caio Santos de Souza, Mariene R. Amorim, João Paulo Cola, Raquel Gomes Catozo, Bruno Luiz M. Guedes, Bruna Caetano Pimenta, Julia Sthefany Nunes Zordan, Yasmim Barcellos Madeira Rosa, Henrique Tamanini Silva Moschen, Aline Souza Areias, Tatiane Comerio, Isabela Valim Sarmento, Julia Miranda Fardin, Daniel Claudio de Oliviera Gomes, Kiven Kumar, Eng Eong Ooi, Camila Malta Romano, Creuza Rachel Vicente   +18 more
wiley   +1 more source

Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

mBio, 2018
One paradigm to explain the complexity of viral RNA populations is that the low fidelity of the RNA-dependent RNA polymerase (RdRp) drives high mutation rates and consequently genetic diversity.
Natalie D. Collins, Andrew S. Beck, Steven G. Widen, Thomas G. Wood, Stephen Higgs, Alan D. T. Barrett   +5 more
doaj   +1 more source

Exploring Erythrina flavonoids as potential SARS-CoV-2 RdRp inhibitors through virtual screening, in silico ADMET evaluation, and molecular dynamics simulation studies

Scientific Reports
The COVID-19 pandemic, caused by SARS-CoV-2, has intensified the search for effective antiviral agents. This study investigates the inhibitory potential of 473 flavonoids from the genus Erythrina against the key enzyme of SARS-CoV-2, RNA-dependent RNA ...
Tati Herlina, Vicki Nishinarizki, Abd. Wahid Rizaldi Akili, Ari Hardianto, Shabarni Gaffar, Muchtaridi Muchtaridi, Jalifah Latip   +6 more
doaj   +1 more source

Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics

Beilstein Journal of Organic Chemistry
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process.
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evžen Bouřa, Radim Nencka   +7 more
doaj   +1 more source

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic. [PDF]

Viruses, 2023
Comunale BA, Larson RJ, Jackson-Ward E, Singh A, Koback FL, Engineer LD.   +5 more
europepmc   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2. [PDF]

Viruses, 2023
Bakheit AH, Saquib Q, Ahmed S, Ansari SM, Al-Salem AM, Al-Khedhairy AA.   +5 more
europepmc   +1 more source