Results 141 to 150 of about 3,624,287 (199)

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source

Structural and functional characterisation of the Crimean-Congo haemorrhagic fever virus RNA dependent RNA polymerase

Nature Communications
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is found across Africa, Asia, and the Middle East where it can cause Haemorrhagic outbreaks with high case fatality rates.
Adrian Deng, Rory Cunnison, Loïc Carrique, Franziska Günl, Els Pardon, Jan Steyaert, David Nguyen Duc, Jonathan M. Grimes, Nicole Robb, Jeremy R. Keown   +9 more
doaj   +1 more source

Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening. [PDF]

Struct Chem, 2023
Jade D, Alzahrani A, Critchley W, Ponnambalam S, Harrison MA.   +4 more
europepmc   +1 more source

A BIOINFORMATICS CHARACTERIZATION OF THE RNA-DEPENDENT RNA POLYMERASE FROM THE PARASITIC FUNGI, Metarhizium anisopliae

Российский паразитологический журнал, 2016
Metarhizium anisopliae is an entomopathogenic organism that is parasitic towards insects, including those that serve as vectors for human disease, including malaria parasite infected Anopheles mosquitoes.
C. N. WEIR, E. EWONG, G. F. KING
doaj  

Structural basis for RNA synthesis and inhibition of the orthobunyavirus polymerase

Nature Communications
Orthobunyaviruses are segmented negative-sense RNA viruses that encompass several life-threatening human and animal pathogens. However, no licensed antivirals are currently available. The viral RNA-dependent RNA polymerase (RdRp) is a multi-domain enzyme
Jingjing Tang, Wenhua Kuang, Wei Chen, Hao Wu, Yong Wang, Jinyue Li, Zhiming Yuan, Han Xia, Haiyan Zhao, Zengqin Deng   +9 more
doaj   +1 more source

In silico study of RNA polymerase inhibitor drugs for Rift Valley fever virus using RdRp protein as the target

Context: Rift Valley fever (RVF) is a disease caused by the RVF virus (RVFV), concentrated mostly in Africa. The virus, usually found in animals, can infect humans through contact with infected animals or mosquito vectors. No established treatment exists,
Mukti Subagja, Juan Lorell, Theophanie Scholastica Tanzil, Arli Aditya Parikesit, Nicolaas Raditya Putra Gautama   +4 more
core   +1 more source

Designing an Epitope-Based Peptide Vaccine Derived from RNA-Dependent RNA Polymerase (RdRp) against Dengue Virus Serotype 2. [PDF]

Vaccines (Basel), 2022
Wahongan IF, Suoth EJ, Fatimawali, Alhumaid S, Albayat H, Aljeldah M, Al Shammari BR, Mashraqi MM, Alshehri AA, Sulaiman T, Turkistani SA, Alwashmi ASS, Garout M, Tallei TE, Rabaan AA.   +14 more
europepmc   +1 more source

Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS-CoV-2: An approach to targeting RNA-dependent RNA polymerase (RdRp). [PDF]

J Food Biochem, 2022
Kuriakose A, Nair B, Abdelgawad MA, Adewum AT, Soliman MES, Mathew B, Nath LR.   +6 more
europepmc   +1 more source

Dengue virus RNA-dependent RNA polymerase (RdRp) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Genome transcription/translation of segmented, negative-strand RNA viruses [PDF]

, 2011
The requirements for alignment of capped RNA leader sequences along the viral genome during influenza transcription initiation (“cap-snatching”) have long been an enigma.
Geerts-Dimitriadou, C.
core