Results 151 to 160 of about 57,300 (174)
Hepatitis C Virus NS5A Binds RNA-Dependent RNA polymerase NS5B and modulates RdRP activity
Hepatitis C Virus NS5A Binds RNA-Dependent RNA polymerase NS5B and modulates RdRP activityopenaire
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA dependent RNA polymerase (RdRp).
Current Medicinal Chemistry, 2021 BACKGROUND SARS-CoV-2, which emerged in Wuhan, China, is a new global threat that has killed millions of people and continues to do so. This pandemic has not only threatened human life but has also triggered economic downturns across the world ...
Shabana Bibi +4 more
semanticscholar +4 more sources
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Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.
European Journal of Medicinal Chemistry, 2021Over recent years, many outbreaks caused by (re)emerging RNA viruses have been reported worldwide, including life-threatening Flaviviruses, such as Dengue (DENV) and Zika (ZIKV). Currently, there is only one licensed vaccine against Dengue, Dengvaxia®. However, its administration is not recommended for children under nine years.
I. Nascimento +4 more
semanticscholar +3 more sources
Journal of Cellular Biochemistry, 2018
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease.
L. Ravichandran +2 more
semanticscholar +3 more sources
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease.
L. Ravichandran +2 more
semanticscholar +3 more sources
RNA-Dependent RNA Polymerase (RdRp)
Springer Series in Biophysics, 2023Jiapu Zhang, Zhang Jiapu
exaly +2 more sources
Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain
BioMedInformatics, 2023 We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species. RdRps have a structurally conserved active site with seven motifs (A to G), despite low sequence similarity.
James N Baraniuk
exaly +3 more sources
Journal of Biomolecular Structure and Dynamics, 2021
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication. We aim to evaluate
Shashank M. Patil +6 more
semanticscholar +1 more source
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the key targets that are involved in the viral genome replication. We aim to evaluate
Shashank M. Patil +6 more
semanticscholar +1 more source
Journal of Physical Chemistry B, 2020
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 treatment for emergency use, targeting RNA-dependent RNA ...
Padmaja D. Wakchaure +2 more
semanticscholar +1 more source
Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 treatment for emergency use, targeting RNA-dependent RNA ...
Padmaja D. Wakchaure +2 more
semanticscholar +1 more source
HADDOCK screening against the COVID-19 RNA dependent RNA polymerase (RdRp)
, 2020 The novel coronavirus (SARS-CoV-2) that has emerged from Wuhan, China in December 2019 has spread to almost all countries in the world causing a dramatic number of deaths.
P. Koukos, M. Réau, A. Bonvin
semanticscholar +2 more sources
Biochemistry & Physiology: Open Access, 2015
Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
openaire +1 more source
Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
openaire +1 more source