Results 151 to 160 of about 3,624,287 (199)

Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations. [PDF]

Sci Rep, 2022
Brunt D, Lakernick PM, Wu C.
europepmc   +1 more source

Structural basis of Nipah virus RNA synthesis

Nature Communications
Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its RNA-dependent RNA polymerase (RdRp) complex, consisting of the
Fernanda A. Sala, Katja Ditter, Olexandr Dybkov, Henning Urlaub, Hauke S. Hillen   +4 more
doaj   +1 more source

Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp). [PDF]

Bioinformation, 2021
Patil SM, Maruthi KR, Bajpe SN, Vyshali VM, Sushmitha S, Akhila C, Ramu R.   +6 more
europepmc   +1 more source

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity. [PDF]

Comput Struct Biotechnol J, 2022
Uengwetwanit T, Chutiwitoonchai N, Wichapong K, Karoonuthaisiri N.   +3 more
europepmc   +1 more source

Reorganizing the RNA polymerase II complex for replication of an infectious noncoding RNA in vivo.

PLoS Pathogens
DNA-dependent RNA polymerases (DdRPs) recognize not only DNA but also RNA templates. This RNA-dependent RNA polymerase (RdRP) activity is exploited by bacterial 6S RNA, mammalian B2 RNA, viroids in plants, and hepatitis delta virus in human.
Jie Hao, Zhuan Qin, Junfei Ma, Jie Qu, Yunhan Wang, Svetlana Y Folimonova, Bin Liu, Wenwei Li, Ying Wang   +8 more
doaj   +1 more source

In silico structural elucidation of the rabies RNA-dependent RNA polymerase (RdRp) toward the identification of potential rabies virus inhibitors. [PDF]

J Mol Model, 2021
Kiriwan D, Choowongkomon K.
europepmc   +1 more source

Establishment of in vitro transcription system based on RNA-dependent RNA polymerase (RdRp) of Little cherry virus 1

Acta virologica, 2021
Xinran, Cao, Yalan, Wang, Guowei, Geng, Yifan, Sun, Chenmeng, Gao, Deya, Wang, Xuefeng, Yuan   +6 more
openaire   +2 more sources

RNA-dependent RNA polymerases in the black-legged tick produce Argonaute-dependent small RNAs and regulate genes [PDF]

Small regulatory RNAs (sRNAs) are involved in anti-viral defense and gene regulation. Although RNA-dependent RNA Polymerases (RdRPs) are known to produce sRNA in nematodes, plants and fungi, whether they play roles in sRNA biogenesis in other animals ...
Okamura, Katsutomo, Feng, Canran, 26389, Iida, Junko, Lim, Mandy Yu Theng, 26384, Torimaru, Kyosuke, 26386, 26385, 26388, Tanaka, Tetsuya, 26387, Tsuji, Kosuke, Chak, Li-Ling, 26391, 26390   +15 more
core  

Targeting the SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) With Synthetic/Designer Unnatural Nucleoside Analogues: An In Silico Study

, 2023
Bag SS, Sinha S, Dutta S, Baishya HJ, Paul S.   +4 more
europepmc   +1 more source

Comparing Force Field Treatments in QM/MM Studies of the SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp) Mechanism. [PDF]

J Chem Theory Comput
Roca M, Maghsoud Y, Cisneros GA, Świderek K, Moliner V.   +4 more
europepmc   +1 more source