Results 131 to 140 of about 34,592 (189)

Cryo-EM structures of Nipah virus polymerases and high-throughput biochemical RdRp assay development enable anti-NiV drug discovery [PDF]

Structural Dynamics
The transcription and replication of Nipah virus (NiV) is driven by the large protein (L) and its essential co-factor phosphoprotein (P). L encodes all the viral enzymatic functions including RNA-dependent RNA polymerase (RdRp) activity while P functions
Ahmed Rohaim, Colin Deniston, Zhenhang Chen, Cosmo Buffolo, Tiffany Tsang, Lilli Xie, Michael DiDonato, Glen Spraggon, Matt Clifton, Nadine Jarrousse, Judith Straimer, Bo Liang   +11 more
doaj   +1 more source

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source

The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)'s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19. [PDF]

Molecules, 2023
Metwally K, Abo-Dya NE, Alahmdi MI, Albalawi MZ, Yahya G, Aljoundi A, Salifu EY, Elamin G, Ibrahim MAA, Sayed Y, Fanucchi S, Soliman MES.   +11 more
europepmc   +1 more source

RNA Dependent RNA Polymerase (RdRP) [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

A BIOINFORMATICS CHARACTERIZATION OF THE RNA-DEPENDENT RNA POLYMERASE FROM THE PARASITIC FUNGI, Metarhizium anisopliae

Российский паразитологический журнал, 2016
Metarhizium anisopliae is an entomopathogenic organism that is parasitic towards insects, including those that serve as vectors for human disease, including malaria parasite infected Anopheles mosquitoes.
C. N. WEIR, E. EWONG, G. F. KING
doaj  

Designing an Epitope-Based Peptide Vaccine Derived from RNA-Dependent RNA Polymerase (RdRp) against Dengue Virus Serotype 2. [PDF]

Vaccines (Basel), 2022
Wahongan IF, Suoth EJ, Fatimawali, Alhumaid S, Albayat H, Aljeldah M, Al Shammari BR, Mashraqi MM, Alshehri AA, Sulaiman T, Turkistani SA, Alwashmi ASS, Garout M, Tallei TE, Rabaan AA.   +14 more
europepmc   +1 more source

Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS-CoV-2: An approach to targeting RNA-dependent RNA polymerase (RdRp). [PDF]

J Food Biochem, 2022
Kuriakose A, Nair B, Abdelgawad MA, Adewum AT, Soliman MES, Mathew B, Nath LR.   +6 more
europepmc   +1 more source

Suppression of Type I Interferon Signaling by Flavivirus NS5. [PDF]

, 2018
Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to ...
Hai, Rong, Song, Jikui, Thurmond, Stephanie, Wang, Boxiao   +3 more
core  

Investigations on Aspergillus fumigatus double-stranded RNAs and their effects on the fungus

, 2011
The aim of this research was to assess the incidence of dsRNA mycoviruses in the opportunistic human pathogenic fungus Aspergillus fumigatus, where previously no dsRNA viruses had been reported and to investigate the effects of any dsRNAs on the growth
Bhatti, Muhammad Faraz, Bhatti, Muhammad Faraz   +1 more
core   +1 more source

Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations. [PDF]

Sci Rep, 2022
Brunt D, Lakernick PM, Wu C.
europepmc   +1 more source