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Mutational analysis of the structure and functions of Hepatitis C Virus RNA-dependent RNA polymerase (RdRP)openaire +1 more source
Hepatitis C Virus NS5A Binds RNA-Dependent RNA polymerase NS5B and modulates RdRP activity
Hepatitis C Virus NS5A Binds RNA-Dependent RNA polymerase NS5B and modulates RdRP activityopenaire +1 more source
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RNA-Dependent RNA Polymerase (RdRp)
Springer Series in Biophysics, 2023Jiapu Zhang
exaly +2 more sources
Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication [PDF]
Journal of Biological Chemistry, 2016 Dengue virus, an ∼10.7-kb positive-sense RNA virus, is the most common arthropod-communicated pathogen in the world. Despite dengue's clear epidemiological importance, mechanisms for its replication remain elusive. Here, we probed the entire dengue genome for interactions with viral RNA-dependent RNA polymerase (RdRp), and we identified the dominant ...
Thawornchai Limjindaporn +2 more
exaly +3 more sources
Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain
BioMedInformatics, 2023 We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species. RdRps have a structurally conserved active site with seven motifs (A to G), despite low sequence similarity.
James Nicholas Baraniuk
exaly +3 more sources
Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors
European Journal of Medicinal Chemistry, 2021Over recent years, many outbreaks caused by (re)emerging RNA viruses have been reported worldwide, including life-threatening Flaviviruses, such as Dengue (DENV) and Zika (ZIKV). Currently, there is only one licensed vaccine against Dengue, Dengvaxia®. However, its administration is not recommended for children under nine years.
Igor José Dos Santos, Nascimento +4 more
openaire +2 more sources
Biochemistry & Physiology: Open Access, 2015
Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
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Nipah virus is an emerging zoonotic paramyxovirus that is responsible for severe outbreaks in humans and livestocks. This negative stranded RNA virus carries RNA-dependent RNA polymerase (RdRp) complex which is required for viral RNA replication and transcription as a catalytic subunit of viral replicase.
Md. Jahangir Alam +2 more
openaire +1 more source
Journal of Cellular Biochemistry, 2018
AbstractPersistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its molecular mechanisms, we utilized the proteome data of NiV to evaluate the potency of three major proteins (phosphoprotein, polymerase, and nucleocapsid ...
Lavanya Ravichandran +2 more
openaire +2 more sources
AbstractPersistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its molecular mechanisms, we utilized the proteome data of NiV to evaluate the potency of three major proteins (phosphoprotein, polymerase, and nucleocapsid ...
Lavanya Ravichandran +2 more
openaire +2 more sources
Potential use of RNA-dependent RNA polymerase (RdRp) inhibitor against COVID-19 infection
2020Favipiravir, an inhibitor of RNA-dependent RNA polymerase used against the Japanese flu, was recently suggested as a potential COVID-19 inhibitor. Since Favipiravir targets a critical and a viral specific process, using it as a treatment could be beneficial in slowing the outbreak.
Charles Allen +3 more
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Conserved amino acids in HCoV-HKU1 and SARS-Cov2 at RNA-dependent RNA polymerase (RdRp) motifs
2021A novel and related to severe acute respiratory syndrome associated coronavirus (SARS-CoV2) has been identified as an infectious coronavirus originating from a Wuhan seafood market and rapidly spreading into and beyond China. While non-conserved regions of viral genome can lead to novel coronavirus subtypes, conserved regions are also very important ...
ATASEVER ARSLAN, Belkis +4 more
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