Results 221 to 230 of about 325,869 (333)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Transcription-replication conflict resolution by nuclear RNA interference. [PDF]

Mol Cell
Cheng T, Roche B, Abderahmane F, Touat-Todeschini L, Fréon K, Lakhani AA, Bhattacharjee S, Spielmann LG, Jenen E, Choi C, Ren J, Verdel A, Lambert SAE, Martienssen RA.   +13 more
europepmc   +1 more source

Evidence for direct involvement of T7 RNA polymerase bacteriophage DNA replication [PDF]

, 1980
David C. Hinkle
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Genome-wide strand-specific UV mutagenesis in <i><i>Escherichia coli</i></i> is directed by the Mfd translocase. [PDF]

Proc Natl Acad Sci U S A
Adebali O, Mieczkowski PA, Sancar A, Selby CP.   +3 more
europepmc   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Fueling chromosomal gene diversification and artificial evolution with CRISPR. [PDF]

Genome Biol
Zhu R, Ren C, Bao Z.
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Transcriptome profiling of human dermal MDPL fibroblasts reveals a characteristic molecular signature providing insights into pathogenic mechanisms. [PDF]

J Mol Med (Berl)
Murdocca M, Pepe G, Maccaroni S, Spitalieri P, Helmer-Citterich M, Novelli G, Sangiuolo F.   +6 more
europepmc   +1 more source

RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus-producing cells: high- and low-molecular-weight forms with variant biochemical and immunological properties.

, 1975
H. Mondal, Robert E. Gallagher, Robert C. Gallo   +2 more
openalex   +2 more sources