Results 211 to 220 of about 203,406 (266)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality. [PDF]

Front Plant Sci
Wijayanti P, Wada Y, Ito T.
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Sam68 stimulates polymerase theta-mediated end-joining by suppressing poison exon inclusion in Polq mRNA. [PDF]

Nucleic Acids Res
van Wezel MD, Kool H, van den Heuvel D, van Schendel R, Barazas M, Luijsterburg MS, Tijsterman M, Schimmel J.   +7 more
europepmc   +1 more source

Engineering of T7 DNA-dependent RNA polymerase with activity at elevated temperature. [PDF]

PLoS One
Hehn S, Gutbrod J, Gutjahr M, Marx A.
europepmc   +1 more source

Detection of Residual Pluripotent Stem Cells in Differentiated Cells-General Requirements for Probe-Based Quantitative PCR Assay. [PDF]

Cell Prolif
Cao J, Xu R, Fu B, Yu J, Na T, Ma A, Hao J, Wang L, Zhao H, Wei Q, Rao C, Wang H, Yang Z, Zhang Y, Zheng Z, Li Q, Zhang W, Chen Q, Hu S, Zhou L, Fan J, Sun S, Xie J, Li C, Zhang T, Gan Y, Wang S, Stacey GN, Wei J, Zhao T, Zhang YA.   +30 more
europepmc   +1 more source

The Oligomeric State of Rad6-Rad18 and Its Interactions with Translesion Synthesis Proteins. [PDF]

Biomolecules
Woodward TJ, Ripley BM, Ling JA, Washington MT.   +3 more
europepmc   +1 more source

RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease. [PDF]

RNA Biol
González-Jiménez A, Medina I, Alfonso MJ, Vázquez de Aldana CR, Calvo O.   +4 more
europepmc   +1 more source

Amplification bias in sequencing-based spatial transcriptomics: sources, mechanisms, impacts, and mitigation strategies. [PDF]

Brief Bioinform
Shan Y, Piao Y, Ge Q.
europepmc   +1 more source