Results 51 to 60 of about 325,869 (333)
Tissue-specific expression from a compound TATA-dependent and TATA-independent promoter [PDF]
, 1990 We have found that the mouse metallothionein-I (MT-I) gene promoter functions in an unusual, compound manner. It directs both TATA-dependent and TATA-independent modes of transcription in vivo.
Garrity, Paul A., Wold, Barbara J.
core +2 more sources
Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]
, 2008 Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
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T4 DNA polymerase improves the efficiency of multiple site-directed mutagenesis
Biotechnology & Biotechnological Equipment, 2016 Site-directed mutagenesis (SDM) is a useful tool to study the functions of regulatory sequences of DNA and RNA, and the structures and functions of proteins. Numerous methods have been developed for either single or multiple SDM (MSDM).
Wei Guo +4 more
doaj +1 more source
Identification of Potential Biomarkers for CAD Using Integrated Expression and Methylation Data
Frontiers in Genetics, 2020 DNA methylation plays an essential role in the pathogenesis of coronary artery disease (CAD) through regulating mRNA expressions. This study aimed to identify hub genes regulated by DNA methylation as biomarkers of CAD.
Xiaokang Zhang +6 more
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A Pol V-mediated silencing, independent of RNA-directed DNA methylation, applies to 5S rDNA. [PDF]
PLoS Genetics, 2009 The plant-specific RNA polymerases Pol IV and Pol V are essential to RNA-directed DNA methylation (RdDM), which also requires activities from RDR2 (RNA-Dependent RNA Polymerase 2), DCL3 (Dicer-Like 3), AGO4 (Argonaute), and DRM2 (Domains Rearranged ...
Julien Douet +2 more
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Molecular Systems Biology, 2014 DNA replication, transcription and repair involve the recruitment of protein complexes that change their composition as they progress along the genome in a directed or strand‐specific manner.
Benedikt Zacher +4 more
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Developments in the tools and methodologies of synthetic biology. [PDF]
, 2014 Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P +3 more
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Emerging connections between small RNAs and phytohormones [PDF]
, 2020 Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke +3 more
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Genome Biology, 2017 Background The chromodomain helicase DNA-binding family of ATP-dependent chromatin remodeling factors play essential roles during eukaryote growth and development.
Rong Yang +13 more
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One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts
Molecules, 2020 There is an increasing demand for efficient and robust production of short RNA molecules in both pharmaceutics and research. A standard method is in vitro transcription by T7 RNA polymerase.
Hannes Feyrer +3 more
doaj +1 more source