On the origin of DNA genomes: evolution of the division of labor between template and catalyst in model replicator systems. [PDF]
PLoS Computational Biology, 2011 The division of labor between template and catalyst is a fundamental property of all living systems: DNA stores genetic information whereas proteins function as catalysts. The RNA world hypothesis, however, posits that, at the earlier stages of evolution,
Nobuto Takeuchi +2 more
doaj +1 more source
Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading [PDF]
Phys. Rev. E 93, 042420 (2016), 2016 Kinetic theory and thermodynamics are applied to DNA polymerases with exonuclease activity, taking into account the dependence of the rates on the previously incorportated nucleotide. The replication fidelity is shown to increase significantly thanks to this dependence at the basis of the mechanism of exonuclease proofreading.
arxiv +1 more source
DNA-directed termination of mammalian RNA polymerase II. [PDF]
Genes DevDavidson L +6 more
europepmc +2 more sources
Morphology and Molecular Phylogeny of Pseudocercospora fatouae Associated with Hypophyllous Leaf Mold on Fatoua villosa in Korea [PDF]
한국균학회지, 2023 Dark brown leaf molds growing in a vein-limited pattern have been continuously observed on the lower leaf surface of Fatoua villosa in Korea.
Kui-Jae Lee +5 more
doaj +1 more source
First-passage problems in DNA replication: effects of template tension on stepping and exonuclease activities of a DNA polymerase motor [PDF]
Journal of Physics: Condensed Matter, vol.25, 374105 (2013), 2013 A DNA polymerase (DNAP) replicates a template DNA strand. It also exploits the template as the track for its own motor-like mechanical movement. In the polymerase mode it elongates the nascent DNA by one nucleotide in each step. But, whenever it commits an error by misincorporating an incorrect nucleotide, it can switch to an exonuclease mode.
arxiv +1 more source
Stochastic resetting in backtrack recovery by RNA polymerases [PDF]
Phys. Rev. E 93, 062411 (2016), 2016 Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template.
arxiv +1 more source
PLoS Pathogens, 2022 ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent remains enigmatic.
Yong Ran +10 more
doaj +1 more source
An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation [PDF]
Nature, 2010 DNA methylation is an important epigenetic mark in many eukaryotes. In plants, 24-nucleotide small interfering RNAs (siRNAs) bound to the effector protein, Argonaute 4 (AGO4), can direct de novo DNA methylation by the methyltransferase DRM2 (refs 2, 4-6). Here we report a new regulator of RNA-directed DNA methylation (RdDM) in Arabidopsis: RDM1.
Thierry Lagrange +24 more
openaire +5 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1975 RNA-directed DNA polymerase (reverse transcriptase) from leukocytes of individual leukemic patients can be grouped by velocity gradient analyses into two distinct classes, a low-molecular-weight (LMW) class of approximately 70,000 and a high-molecular ...
H. Mondal, R. Gallagher, R. Gallo
semanticscholar +1 more source
The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase.
PLoS ONE, 2013 UvrD-like helicases play diverse roles in DNA replication, repair and recombination pathways. An emerging body of evidence suggests that their different cellular functions are directed by interactions with partner proteins that target unwinding activity ...
Emma J Gwynn +5 more
doaj +1 more source