Results 31 to 40 of about 326,612 (309)

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue. [PDF]

, 2016
The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic
Da, Lin-Tai, Gao, Xin, Huang, Xuhui, Pardo-Avila, Fátima, Silva, Daniel-Adriano, Wang, Dong, Xu, Liang, Zhang, Lu   +7 more
core   +2 more sources

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity

Biology, 2012
HIV-1 enzyme reverse transcriptase (RT) is a major target for antiviral drug development, with over half of current FDA-approved therapeutics against HIV infection targeting the DNA polymerase activity of this enzyme. HIV-1 RT is a multifunctional enzyme
Michael A. Parniak, Stefan G. Sarafianos, Rieko Ishima, Krystal LaBarge, Tatiana Ilina   +4 more
doaj   +1 more source

Inhibition of RNA-directed DNA polymerase by aurintricarboxylic acid.

Nucleic Acids Research, 1976
Commercial-grade aurintricarboxylic acid (ATA) inhibits poly(A), poly(C) and viral RNA-directed DNA synthesis by detergent-disrupted virions of Moloney murine leukemia virus. Paper chromatography of crude ATA yields two active components, which appear to behave identically, and at least two inactive components.
J F, Givens, K F, Manly
openaire   +3 more sources

Developments in the tools and methodologies of synthetic biology. [PDF]

, 2014
Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P, Kelwick, R, MacDonald, JT, Webb, AJ   +3 more
core   +1 more source

On the origin of DNA genomes: evolution of the division of labor between template and catalyst in model replicator systems. [PDF]

PLoS Computational Biology, 2011
The division of labor between template and catalyst is a fundamental property of all living systems: DNA stores genetic information whereas proteins function as catalysts. The RNA world hypothesis, however, posits that, at the earlier stages of evolution,
Nobuto Takeuchi, Paulien Hogeweg, Eugene V Koonin   +2 more
doaj   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source

Kinetic analysis of an efficient DNA-dependent TNA polymerase. [PDF]

, 2005
alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs).
Chaput, John C, Horhota, Allen, Ichida, Justin K, McLaughlin, Larry W, Szostak, Jack W, Yu, Biao, Zou, Keyong   +6 more
core   +2 more sources

Human placentas contain a specific inhibitor of RNA-directed DNA polymerase. [PDF]

Proceedings of the National Academy of Sciences, 1981
Human placental extracts contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) activity. This inhibitor copurifies with retrovirus-like particles in human placental extracts.
J A, Nelson, J A, Levy, J C, Leong
openaire   +2 more sources

Characterization of endogenous RNA-directed DNA polymerase activity of reticuloendotheliosis viruses [PDF]

Journal of Virology, 1975
Reticuloendotheliosis viruses (REV) contain an endogenous RNA-directed DNA polymerase activity. The endogenous DNA polymerase activity can be elicited in purified preparations of REV by treatment with nonionic detergents. The enzyme activity has a strong preference for manganous ions.
openaire   +2 more sources