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RNA–Protein Interactions: An Overview
2013RNA binding proteins (RBPs) are key players in the regulation of gene expression. In this chapter we discuss the main protein-RNA recognition modes used by RBPs in order to regulate multiple steps of RNA processing. We discuss traditional and state-of-the-art technologies that can be used to study RNAs bound by individual RBPs, or vice versa, for both ...
Re A +4 more
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Current Opinion in Structural Biology, 2002
Recent discoveries have revealed that there is a myriad of RNAs and associated RNA-binding proteins that spatially and temporally appear in the cells of all organisms. The structures of these RNA-protein complexes are providing valuable insights into the binding modes and functional implications of these interactions.
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Recent discoveries have revealed that there is a myriad of RNAs and associated RNA-binding proteins that spatially and temporally appear in the cells of all organisms. The structures of these RNA-protein complexes are providing valuable insights into the binding modes and functional implications of these interactions.
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RNA-protein interactions in spherical viruses
Archives of Virology, 2002The three-dimensional structure of many non-enveloped spherical RNA viruses has been determined in great detail, mainly using X-ray crystallography. Great insight in the structure of the protein capsid has been obtained, but much less information is available about the secondary and tertiary structure of the RNA in situ, due to a number of ...
H H J, Bink, C W A, Pleij
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Mapping of RNA–protein interactions
Analytica Chimica Acta, 2009RNA-protein interactions are important biological events that perform multiple functions in all living organisms. The wide range of RNA interactions demands diverse conformations to provide contacts for the selective recognition of proteins. Various analytical procedures are presently available for quantitative analyses of RNA-protein complexes, but ...
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2022
In this chapter, the chemical principles that underlie protein–RNA interactions are examined and the fundamental mechanisms by which proteins associate with specific targets in RNA molecules are identified. Although RNA binding proteins (RBPs) are similar to DNA binding proteins in terms of the variety of non-covalent interactions that dominate the ...
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In this chapter, the chemical principles that underlie protein–RNA interactions are examined and the fundamental mechanisms by which proteins associate with specific targets in RNA molecules are identified. Although RNA binding proteins (RBPs) are similar to DNA binding proteins in terms of the variety of non-covalent interactions that dominate the ...
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Methods to study the RNA-protein interactions
Molecular Biology, 2015RNA-binding proteins (RBPs) play an important role in regulating gene expression at the posttranscriptional level, including the steps of pre-mRNA splicing, polyadenylation, mRNA stabilization, mRNA export from the nucleus to the cytoplasm, mRNA localization, and translation.
V V, Popova +2 more
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Current Opinion in Structural Biology, 1992
Abstract Recent biochemical experiments have revealed the secondary structural elements of RNA that are recognized by various RNA-binding proteins. These include structures such as hairpins, bulges, bubbles and pseudoknots that are distinct from the double-stranded form.
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Abstract Recent biochemical experiments have revealed the secondary structural elements of RNA that are recognized by various RNA-binding proteins. These include structures such as hairpins, bulges, bubbles and pseudoknots that are distinct from the double-stranded form.
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Computational Prediction of RNA-Protein Interactions
2017Experimental methods for identifying protein(s) bound by a specific promoter-associated RNA (paRNA) of interest can be expensive, difficult, and time-consuming. This chapter describes a general computational framework for identifying potential binding partners in RNA-protein complexes or RNA-protein interaction networks.
Carla M, Mann +2 more
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RNA–Protein Interaction Analysis
2021RNA-binding proteins (RBPs) play very crucial role in various physiological and biochemical functions of cells. It is a well-known fact that proteins are the key component of cell through which various functions of cells are regulated as they are receptors, adaptors, and enzymes.
Sushil Kumar Rathore, Pallabi Pati
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M(R)apping RNA–Protein Interactions
2021The systematic investigation of RNA-protein interactions is a key step towards a better understanding of the functions of RNA molecules.We developed an easy-to-use method to isolate and identify RNAs and proteins bound to long non-coding RNAs (lncRNAs ) in their native configuration.
Jasmine, Barra +2 more
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