Results 241 to 250 of about 567,059 (348)

INTERPRETING PERSONAL TRANSCRIPTOMES: PERSONALIZED MECHANISM-SCALE PROFILING OF RNA-SEQ DATA [PDF]

, 2012
Alan Perez-Rathke, Haiquan Li, Yves A. Lussier   +2 more
openalex   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Seed shattering in common buckwheat (Fagopyrum esculentum): insights from RNA-seq and morphological analysis. [PDF]

BMC Plant Biol
Gunko EM, Schelkunov MI, Prokopchuk SR, Klepikova AV, Omelchenko DO, Romanova OI, Fesenko AN, Fesenko IN, Penin AA, Logacheva MD.   +9 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Protocol for mapping 2'-O-methylation using nanopore direct RNA-seq data with NanoNm. [PDF]

STAR Protoc
Li Y, Chen J, Wang Y, Li D, Li J, Yi Y, Zhang L, Cao Q, Chen K.   +8 more
europepmc   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

scDown: A Pipeline for Single-Cell RNA-Seq Downstream Analysis. [PDF]

Int J Mol Sci
Sun L, Ma Q, Cai C, Labaf M, Jain A, Dias C, Rockowitz S, Sliz P.   +7 more
europepmc   +1 more source

cDNA normalization by hydroxyapatite chromatography to enrich transcriptome diversity in RNA-seq applications

, 2012
Victoria A. VanderNoot, Stanley A. Langevin, Owen D. Solberg, Pamela Lane, Deanna Joy Curtis, Zachary Bent, Kelly P. Williams, Kamlesh D. Patel, Joseph S. Schoeniger, Steven S. Branda, Todd W. Lane   +10 more
openalex   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Transcriptional regulation of nucleotide metabolism in medulloblastoma subtypes and prognostic implications analyzed by RNA-Seq. [PDF]

J Cancer Res Clin Oncol
Huang R, Lu X, Sun X, Wu H.
europepmc   +1 more source