Results 251 to 260 of about 591,228 (346)

Recovery and analysis of transcriptome subsets from pooled single-cell RNA-seq libraries

, 2018
Kent Riemondy, Monica Ransom, Christopher P Alderman, Austin E. Gillen, Rui Fu, Jay R. Hesselberth   +5 more
openalex   +2 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Integrating Iso-seq and RNA-seq data for the reannotation of the killifish telencephalon transcriptome. [PDF]

Sci Data
Ayana R, Krutikhina T, Van Houcke J, Zandecki C, Mariën V, Maes GE, Seuntjens E, Arckens L.   +7 more
europepmc   +1 more source

Revealing Missing Human Protein Isoforms Based on Ab Initio Prediction, RNA-seq and Proteomics

, 2015
Zhiqiang Hu, Hamish S. Scott, Guangrong Qin, Guangyong Zheng, Xixia Chu, Lu Xie, David L. Adelson, Bergithe E Oftedal, Parvathy Venugopal, Milena Babic, Christopher N Hahn, Bing Zhang, Xiao‐Jing Wang, Nan Li, Chaochun Wei   +14 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Conformal inference for reliable single cell RNA-seq annotation. [PDF]

Bioinformatics
López-De-Castro M, García-Galindo A, González-Gomariz J, Armañanzas R.   +3 more
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Harnessing Single-Cell RNA-Seq for Computational Drug Repurposing in Cancer Immunotherapy. [PDF]

Pharmaceuticals (Basel)
Cheng OJ, Tran TTT, Chen YA, Tan AC.
europepmc   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Bulk RNA-seq deconvolution heterogeneity across paired pancreatic cancer human samples. [PDF]

Front Genet
Jansen RJ, Munro SA, Antwi SO, Rabe KG, Sicotte H.   +4 more
europepmc   +1 more source