Results 121 to 130 of about 4,315,290 (339)

RNA-electroporated T cells for cancer immunotherapy

OncoImmunology, 2020
Adoptive T cell therapy has proven effective against hematologic malignancies and demonstrated efficacy against a variety of solid tumors in preclinical studies and clinical trials.
Fernanda Pohl-Guimarães, Lan B. Hoang-Minh, Duane A. Mitchell   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Lymphocytic RNA stimulates physiological regeneration and enhances microcirculation in the thyroid gland

Вестник трансплантологии и искусственных органов
Objective: to investigate the regulatory effects of exogenous lymphocyte RNA on thyroid gland regeneration.Materials and methods. The study was conducted on 18 male Wistar rats (310–350 g), divided into three groups (n = 6 per group).
N. V. Tishevskaya, E. S. Golovneva, R. V. Takhaviev   +2 more
doaj   +1 more source

RNA synthetic mechanisms employed by diverse families of RNA viruses [PDF]

, 2013
Sarah M. McDonald
openalex   +1 more source

RNA-sequencing and Mathematical Modeling Identify Suite of Light-sensitive Circadian Genes in an Orb-web Weaving Spider [PDF]

, 2021
Natalia Toporikova, Wenduo Cheng, Leyuan Qian, Andrew Mah, Thomas H. Clarke, Thomas C. Jones, Darrell Moore, Nadia A. Ayoub   +7 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway

Bone & Joint Research
Aims: To investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism.
Chen Yao, Jie Sun, Wanxin Luo, Hao Chen, Tianhao Chen, Cao Chen, Bo Zhang, Yafeng Zhang   +7 more
doaj   +1 more source

In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency [PDF]

, 2008
Yoshifumi Takei, Toshio Nemoto, Ping Mu, Tatsuya Fujishima, Takuji Ishimoto, Yasuhiko Hayakawa, Yukio Yuzawa, Seiichi Matsuo, Takashi Muramatsu, Kenji Kadomatsu   +9 more
openalex   +1 more source

Quantitative RNA Analysis Using RNA-Seq

, 2019
High-throughput sequencing of cDNA copies of mRNA (RNA-seq) provides a digital readout of mRNA levels over several orders of magnitude, as well as mapping the transcripts to the nucleotide level. Here we describe two different RNA-seq approaches, including one that exploits the 39-nucleotide mini-exon or spliced leader (SL) sequence found at the 5' end
Myler, P. J., McDonald, Jacqueline A., Alcolea, Pedro J., Sur, Aakash   +3 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source