Results 141 to 150 of about 768,957 (268)

Lymphocytic RNA stimulates physiological regeneration and enhances microcirculation in the thyroid gland

Вестник трансплантологии и искусственных органов
Objective: to investigate the regulatory effects of exogenous lymphocyte RNA on thyroid gland regeneration.Materials and methods. The study was conducted on 18 male Wistar rats (310–350 g), divided into three groups (n = 6 per group).
N. V. Tishevskaya, E. S. Golovneva, R. V. Takhaviev   +2 more
doaj   +1 more source

Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey [PDF]

Iranian Journal of Basic Medical Sciences
Nanomedicine has transformed therapeutic strategies by enabling precise delivery of nucleic acid-based drugs, including small interfering RNA (siRNA), messenger RNA (mRNA), and antisense oligonucleotides.
Dilpreet Singh, Satvir Singh, Nitin Tandon, Akshay Thakur, Neena Bedi   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A comprehensive comparison of comparative RNA structure prediction approaches

, 2004
Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R., Gardner, Paul P., Gardner, P. P., Paul P Gardner, Robert Giegerich, Giegerich, Robert, Giegerich Robert, Gardner Paul P   +7 more
core   +1 more source

Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway

Bone & Joint Research
Aims: To investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism.
Chen Yao, Jie Sun, Wanxin Luo, Hao Chen, Tianhao Chen, Cao Chen, Bo Zhang, Yafeng Zhang   +7 more
doaj   +1 more source

RNA Captor: A Tool for RNA Characterization

PLoS ONE, 2011
In the genome era, characterizing the structure and the function of RNA molecules remains a major challenge. Alternative transcripts and non-protein-coding genes are poorly recognized by the current genome-annotation algorithms and efficient tools are needed to isolate the less-abundant or stable RNAs.A universal RNA-tagging method using the T4 RNA ...
openaire   +7 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

RNA Movies 2: sequential animation of RNA secondary structures

, 2007
Kaiser A, Krüger J, Evers DJ. RNA Movies 2: sequential animation of RNA secondary structures. NUCLEIC ACIDS RESEARCH.
Krüger, Jan, Evers, Dirk J., Kaiser, Alexander   +2 more
core   +1 more source

Identification of the molecular link: STAT3 is a shared key gene linking postmenopausal osteoporosis and sarcopenia

Bone & Joint Research
Aims: This study explored the shared genetic traits and molecular interactions between postmenopausal osteoporosis (POMP) and sarcopenia, both of which substantially degrade elderly health and quality of life.
Dian Liu, Ke Wang, Jinpeng Wang, Fangming Cao, Lin Tao   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source