Results 271 to 280 of about 3,122,867 (388)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

KnockRBP: an integrated multi-omics database of functional perturbation profiles for RNA-binding proteins. [PDF]

Nucleic Acids Res
Yang M, Li J, Liu J, Lu X, Zhou X, Xu Y.
europepmc   +1 more source

Additional file 7 of Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise

Yang Yang, H. Chen, Qìng Yu, Chen Qw, Xinyue Zhou, Shanshan Zhou, Tingjiao Liu, Jinghan Lin   +7 more
openalex   +1 more source

A Map of Drosophila melanogaster Small Nuclear RNA-activating Protein Complex (DmSNAPc) Domains Involved in Subunit Assembly and DNA Binding [PDF]

, 2009
Ko‐Hsuan Hung, M. Brandon Titus, Shu‐Chi Chiang, William E. Stumph   +3 more
openalex   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities. [PDF]

Acta Pharm Sin B
Shi Y, Feng D, Zhou J, Liu L, Li X, Yuan Z, Wu J, Yao H.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Correction: The effects of leukocyte^'s RNA-binding proteins on the immune responses of dogs infected with canine parvovirus. [PDF]

BMC Vet Res
Khosravi M, Bakhshandeh M, Mosallanejad B.   +2 more
europepmc   +1 more source

The RNA‐binding protein Imp2 regulates oxidative phosporylation that is key to glioblastoma cancer stem cell maintenance

, 2012
Michalina Janiszewska, Mario-Luca Suvà, Riekelt H. Houtkooper, Virginie Clément‐Schatlo, Ivan Stamenkovic   +4 more
openalex   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source