Results 171 to 180 of about 92,611 (279)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Measurement of ATP utilization in RNA unwinding and RNA chaperone activities by DEAD-box helicase proteins. [PDF]

Methods Enzymol, 2022
Jarmoskaite I, Helmers AE, Russell R.
europepmc   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

Identification of small RNAs associated with RNA chaperone Hfq reveals a new stress response regulator in <i>Actinobacillus pleuropneumoniae</i>. [PDF]

Front Microbiol, 2022
da Silva GC, Rossi CC, Rosa JN, Sanches NM, Cardoso DL, Li Y, Witney AA, Gould KA, Fontes PP, Callaghan AJ, Bossé JT, Langford PR, Bazzolli DMS.   +12 more
europepmc   +1 more source

Sisyphus observed: Unraveling the high ATP usage of an RNA chaperone. [PDF]

J Biol Chem, 2021
Duran EC, Walter NG.
europepmc   +1 more source

RNA chaperone activity and RNAbinding properties of the E. coli protein StpA

, 2007
The E. coli protein StpA has RNA annealing and strand displacement activities and it promotes folding of RNAs by loosening their structures. To understand the mode of action of StpA, we analysed the relationship of its RNA chaperone activity to its RNA ...
Robert Konrat, Christina Lorenz, Oliver Mayer, Lukas Rajkowitsch   +3 more
core  

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

NMR resonance assignments of the FinO-domain of the RNA chaperone RocC. [PDF]

Biomol NMR Assign, 2021
Eidelpes R, Kim HJ, Glover JNM, Tollinger M.   +3 more
europepmc   +1 more source

Analysis of RNA chaperone activity of truncated ribosomal protein S12 from E.coli and of eukaryal and archaeal S12 orthologues

, 2010
RNA Moleküle sind sowohl strukturell als auch funktionell sehr flexibel. Zum Erlangen ihrer nativen Konformation benötigen sie daher die Hilfe von RNA Chaperonen. RNA Chaperone sind Proteine die missgefaltete RNA Strukturen reparieren können bzw.
Lopez, Martin Alexander
core