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Global Analysis of RNA Secondary Structure in Two Metazoans
Cell Reports, 2012 The secondary structure of RNA is necessary for its maturation, regulation, processing, and function. However, the global influence of RNA folding in eukaryotes is still unclear.
Fan Li +15 more
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Secrets of RNA folding revealed [PDF]
Structure, 1996 The structure of a domain of the group I intron, the largest structure of an RNA to date, reveals structural details of tertiary interactions required for the folding of a large RNA.
Price, Stephen, Nagai, Kiyoshi
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RNA can function as molecular chaperone for RNA folding
Giant, 2020 RNAs can mimic the information storage, replication and catalysis functions of DNAs and proteins, providing physical evidence for the widely accepted RNA world hypothesis that RNA alone constitutes earlier life forms.
Zhi-Chao Lei +8 more
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RNA hairpin-folding kinetics [PDF]
Proceedings of the National Academy of Sciences, 2002 Based on the complete ensemble of hairpin conformations, a statistical mechanical model that combines the eigenvalue solutions of the rate matrix and the free-energy landscapes has been able to predict the temperature-dependent folding rate, kinetic intermediates, and folding pathways for hairpin-forming RNA sequences.
Wenbing, Zhang, Shi-Jie, Chen
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Nature Communications, 2016 Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural ...
Yi Xue +4 more
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Inverse folding of RNA pseudoknot structures
Algorithms for Molecular Biology, 2010 Background RNA exhibits a variety of structural configurations. Here we consider a structure to be tantamount to the noncrossing Watson-Crick and G-U-base pairings (secondary structure) and additional cross-serial base pairs.
Li Linda YM +2 more
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, 2007 In recent years it has become evident that functional RNAs in living organisms are not just curious remnants from a primordial RNA world but a ubiquitous phenomenon complementing protein enzyme based activity. Functional RNAs, just like proteins, depend in many cases upon their well-defined and evolutionarily conserved three-dimensional structure.
Hofacker, Ivo L., Stadler, Peter F.
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RNA pseudoknots: folding and finding [PDF]
F1000 Biology Reports, 2010 RNA pseudoknots are important for function. Three-dimensional structural information is available, insights into factors affecting pseudoknot stability are being reported, and computer programs are available for predicting pseudoknots.
Liu, Biao +2 more
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TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures. [PDF]
PLoS Computational Biology, 2010 The prediction of functional RNA structures has attracted increased interest, as it allows us to study the potential functional roles of many genes. RNA structure prediction methods, however, assume that there is a unique functional RNA structure and ...
Nicholas J P Wiebe, Irmtraud M Meyer
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Nucleic Acids Research, 1984 The folding of single-stranded RNA into its secondary structure is postulated to be equivalent to the simple rule that the next double-helical region (stem) to form is the one with the largest equilibrium constant. The rule is tested and shown to give results consistent with the enzyme cleavage data of several sequences.
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