Results 41 to 50 of about 247,454 (281)
Global Analysis of RNA Secondary Structure in Two Metazoans
Cell Reports, 2012 The secondary structure of RNA is necessary for its maturation, regulation, processing, and function. However, the global influence of RNA folding in eukaryotes is still unclear.
Fan Li +15 more
doaj +1 more source
RNA can function as molecular chaperone for RNA folding
Giant, 2020 RNAs can mimic the information storage, replication and catalysis functions of DNAs and proteins, providing physical evidence for the widely accepted RNA world hypothesis that RNA alone constitutes earlier life forms.
Zhi-Chao Lei +8 more
doaj +1 more source
An RNA foldability metric; implications for the design of rapidly foldable RNA sequences [PDF]
, 2005 Evidence is presented suggesting, for the first time, that the protein foldability metric sigma=(T_theta - T_f)/T_theta, where T_theta and T_f are, respectively, the collapse and folding transition temperatures, could be used also to measure the ...
Ancel +13 more
core +1 more source
Coupled dynamics of RNA folding and nanopore translocation [PDF]
, 2005 The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base-pairing theoretically, using kinetic Monte Carlo simulations
B. Alberts +4 more
core +2 more sources
Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]
, 2017 The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics.
Ansari, Anjum +7 more
core +3 more sources
TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures. [PDF]
PLoS Computational Biology, 2010 The prediction of functional RNA structures has attracted increased interest, as it allows us to study the potential functional roles of many genes. RNA structure prediction methods, however, assume that there is a unique functional RNA structure and ...
Nicholas J P Wiebe, Irmtraud M Meyer
doaj +1 more source
Nature Communications, 2016 Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural ...
Yi Xue +4 more
doaj +1 more source
Statistical mechanics of RNA folding: a lattice approach [PDF]
, 2003 We propose a lattice model for RNA based on a self-interacting two-tolerant trail. Self-avoidance and elements of tertiary structure are taken into account.
A. Pagnani +30 more
core +1 more source
Rapid compaction during RNA folding [PDF]
Proceedings of the National Academy of Sciences, 2002 We have used small angle x-ray scattering and computer simulations with a coarse-grained model to provide a time-resolved picture of the global folding process of the Tetrahymena group I RNA over a time window of more than five orders of magnitude.
Rick, Russell +10 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source