Results 31 to 40 of about 247,454 (281)
Nature Communications, 2023 T-box riboswitches are unique riboregulators where gene regulation is mediated through interactions between two highly structured RNAs. Despite extensive structural insights, how RNA-RNA interactions drive the folding and structural transitions of T-box ...
Xiaolin Niu +5 more
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A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
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Coupling Between Production of Ribosomal RNA and Maturation: Just at the Beginning
Frontiers in Molecular Biosciences, 2021 Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35S/47S in yeast/human) is achieved by up to hundreds of RNA polymerase I (Pol I) enzymes simultaneously transcribing a single ...
Chaima Azouzi +7 more
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RNA folding on the 3D triangular lattice
BMC Bioinformatics, 2009 Background Difficult problems in structural bioinformatics are often studied in simple exact models to gain insights and to derive general principles. Protein folding, for example, has long been studied in the lattice model.
Mayne Martin +2 more
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On the predictibility of A-minor motifs from their local contexts
RNA Biology, 2022 This study investigates the importance of the structural context in the formation of a type I/II A-minor motif. This very frequent structural motif has been shown to be important in the spatial folding of RNA molecules.
Coline Gianfrotta +4 more
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Synthetic biology tools to promote the folding and function of RNA aptamers in mammalian cells
RNA Biology, 2023 RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents.
Qian Hou, Samie R. Jaffrey
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Force-induced misfolding in RNA [PDF]
, 2009 RNA folding is a kinetic process governed by the competition of a large number of structures stabilized by the transient formation of base pairs that may induce complex folding pathways and the formation of misfolded structures. Despite of its importance
D. Herschlag +5 more
core +3 more sources
Folding Kinetics of Large RNAs [PDF]
Journal of Molecular Biology, 2008 We introduce here a heuristic approach to kinetic RNA folding that constructs secondary structures by stepwise combination of building blocks. These blocks correspond to subsequences and their thermodynamically optimal structures. These are determined by the standard dynamic programming approach to RNA folding.
Wolfinger, Michael +8 more
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Thermodynamics of a model for RNA folding [PDF]
, 2008 We analyze the thermodynamic properties of a simplified model for folded RNA molecules recently studied by G. Vernizzi, H. Orland, A. Zee (in {\it Phys. Rev. Lett.} {\bf 94} (2005) 168103).
F. Mandl +7 more
core +2 more sources
, 2007 In recent years it has become evident that functional RNAs in living organisms are not just curious remnants from a primordial RNA world but a ubiquitous phenomenon complementing protein enzyme based activity. Functional RNAs, just like proteins, depend in many cases upon their well-defined and evolutionarily conserved three-dimensional structure.
Hofacker, Ivo L., Stadler, Peter F.
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