Results 11 to 20 of about 143,515 (300)
Transient RNA–protein interactions in RNA folding [PDF]
FEBS Journal, 2011 The RNA folding trajectory features numerous off‐pathway folding traps, which represent conformations that are often equally as stable as the native functional ones. Therefore, the conversion between these off‐pathway structures and the native correctly folded ones is the critical step in RNA folding. This process, referred to as RNA refolding, is slow,
Renee Schroeder, Boris Fürtig
exaly +4 more sources
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractA general overview of the questions and problems in RNA folding is presented. Topics include the differences in the folding problems/questions that apply to RNA versus proteins, methods for determination of final structures, folding versus unfolding, resolution of space and time, and conformational switching.
Crothers, Donald M., Donald M. Crothers
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Perspectives on Viral RNA Genomes and the RNA Folding Problem [PDF]
Viruses, 2020 Viral RNA genomes change shape as virus particles disassemble, form replication complexes, attach to ribosomes for translation, evade host defense mechanisms, and assemble new virus particles.
Susan J. Schroeder
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RNA Chaperones and the RNA Folding Problem [PDF]
Journal of Biological Chemistry, 1995 Functional and structural inter-relationships of RNA and proteins in the execution and control of biological processes such as RNA processing, RNA splicing, and translation are increasingly apparent. In this minireview, I present an RNA chaperone hypothesis, which fosters the view that constraints imposed by fundamental problems in the folding of RNA ...
Daniel Herschlag
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A comparison of RNA folding measures [PDF]
BMC Bioinformatics, 2005 Background In the last few decades there has been a great deal of discussion concerning whether or not noncoding RNA sequences (ncRNAs) fold in a more well-defined manner than random sequences.
Gardner Paul P +2 more
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RNA folding in living cells [PDF]
RNA Biology, 2010 RNA folding is the most essential process underlying RNA function. While significant progress has been made in understanding the forces driving RNA folding in vitro, exploring the rules governing intracellular RNA structure formation is still in its infancy.
Georgeta, Zemora, Christina, Waldsich
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Protein solubility and folding enhancement by interaction with RNA. [PDF]
PLoS ONE, 2008 While basic mechanisms of several major molecular chaperones are well understood, this machinery has been known to be involved in folding of only limited number of proteins inside the cells. Here, we report a chaperone type of protein folding facilitated
Seong Il Choi +12 more
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Folding Kinetics of Large RNAs [PDF]
Journal of Molecular Biology, 2008 We introduce here a heuristic approach to kinetic RNA folding that constructs secondary structures by stepwise combination of building blocks. These blocks correspond to subsequences and their thermodynamically optimal structures. These are determined by the standard dynamic programming approach to RNA folding.
Wolfinger, Michael +8 more
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Free energy landscape and multiple folding pathways of an H-type RNA pseudoknot. [PDF]
PLoS ONE, 2015 How RNA sequences fold to specific tertiary structures is one of the key problems for understanding their dynamics and functions. Here, we study the folding process of an H-type RNA pseudoknot by performing a large-scale all-atom MD simulation and bias ...
Yunqiang Bian +4 more
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TBI server: a web server for predicting ion effects in RNA folding. [PDF]
PLoS ONE, 2015 Metal ions play a critical role in the stabilization of RNA structures. Therefore, accurate prediction of the ion effects in RNA folding can have a far-reaching impact on our understanding of RNA structure and function. Multivalent ions, especially Mg²⁺,
Yuhong Zhu, Zhaojian He, Shi-Jie Chen
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