Results 61 to 70 of about 143,515 (300)
Pseudoknots in RNA folding landscapes [PDF]
Bioinformatics, 2015 Abstract Motivation: The function of an RNA molecule is not only linked to its native structure, which is usually taken to be the ground state of its folding landscape, but also in many cases crucially depends on the details of the folding pathways such as stable folding intermediates or the timing of the folding process itself. To model
Marcel Kucharík +3 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Saxena, Krishna +6 more
core +1 more source
Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]
, 2012 In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
RNA Movies 2: sequential animation of RNA secondary structures
, 2007 Kaiser A, Krüger J, Evers DJ. RNA Movies 2: sequential animation of RNA secondary structures. NUCLEIC ACIDS RESEARCH.
Krüger, Jan +2 more
core +1 more source
BarMap: RNA folding on dynamic energy landscapes
, 2022 S.1308-1316Dynamical changes of RNA secondary structures play an important role in the function of many regulatory RNAs. Such kinetic effects, especially in time-variable and externally triggered systems, are usually investigated by means of extensive ...
Heine, Christian +5 more
core +1 more source
Puf6 primes 60S pre-ribosome nuclear export at low temperature
Nature Communications, 2021 Ribosome biogenesis is crucially dependent on proper rRNA folding, a process assisted by chaperones. Here the authors reveal how Puf6 promotes correct rRNA folding at low temperature, a condition where mis-paired RNA folding intermediates frequently ...
Stefan Gerhardy +11 more
doaj +1 more source
Compact Intermediates in RNA Folding [PDF]
Annual Review of Biophysics, 2010 Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions.
openaire +2 more sources
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source