Results 251 to 260 of about 92,611 (279)

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Escorting mRNAs - the multifunctional and divergent roles of cap-chaperones in post-transcriptional gene expression. [PDF]

J Cell Sci
Embree CM, Borden KLB.
europepmc   +1 more source

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Functional effects of variants of the RNA chaperone Hfq

Biochemical and Biophysical Research Communications, 2004
The ring-shaped RNA chaperone Hfq has recently received much attention owing to its multiple roles in RNA metabolism. In this study we have performed a mutational analysis of the Escherichia coli hfq gene, and have studied the effects of amino acid substitutions at several positions in the Hfq protein as well as of C-terminal truncations on its role in
Elisabeth Sonnleitner, Branislav Večerek, Isabella Moll   +2 more
exaly   +3 more sources

RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins

FEBS Letters, 2011
In this study we showed that the dengue virus (DENV) core protein forms a dimer with an α-helix-rich structure, binds RNA and facilitates the strand annealing process.
Zhi-Shun Huang, Pak-Guan Teoh, Huey-Nan Wu   +2 more
exaly   +2 more sources

RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif

Journal of Biological Chemistry, 2012
La proteins are conserved factors in eukaryotes that bind and protect the 3' trailers of pre-tRNAs from exonuclease digestion via sequence-specific recognition of UUU-3'OH.
Maria R Conte, Mark A Bayfield
exaly   +2 more sources

Ribosomal RNA Methyltransferase RsmC Moonlights as an RNA Chaperone

ChemBioChem, 2020
AbstractRibosomes are ribonucleoprotein particles that are essential for protein biosynthesis in all forms of life. During ribosome biogenesis, transcription, folding, modification, and processing of rRNA are coupled to the assembly of proteins. Various assembly factors are required to synchronize all different processes that occur during ribosome ...
Keshav GC, Prabesh Gyawali, Hamza Balci, Sanjaya Abeysirigunawardena   +3 more
openaire   +2 more sources

RNA chaperone activity of the tombusviral p33 replication protein facilitates initiation of RNA synthesis by the viral RdRp in vitro

Virology, 2011
Small plus-stranded RNA viruses do not code for RNA helicases that would facilitate the proper folding of viral RNAs during replication. Instead, these viruses might use RNA chaperones as shown here for the essential p33 replication protein of Tomato ...
Nikolay Kovalev, Zsuzsanna Sasvári, Peter D Nagy   +2 more
exaly   +2 more sources

The FinO family of bacterial RNA chaperones

Plasmid, 2015
Antisense RNAs have long been known to regulate diverse aspects of plasmid biology. Here we review the FinOP system that modulates F plasmid gene expression through regulation of the F plasmid transcription factor, TraJ. FinOP is a two component system composed of an antisense RNA, FinP, which represses TraJ translation, and a protein, FinO, which is ...
J N, Mark Glover, Steven G, Chaulk, Ross A, Edwards, David, Arthur, Jun, Lu, Laura S, Frost   +5 more
openaire   +2 more sources

Plant RNA chaperones in stress response

Trends in Plant Science, 2013
Post-transcriptional regulation of RNA metabolism is a key regulatory process in diverse cellular processes, including the stress response of plants, during which a variety of RNA-binding proteins (RBPs) function as central regulators in cells. RNA chaperones are RBPs found in all living organisms and function by providing assistance to the correct ...
Hunseung, Kang, Su Jung, Park, Kyung Jin, Kwak   +2 more
openaire   +2 more sources

Assays for the RNA chaperone activity of proteins

Biochemical Society Transactions, 2005
Proteins with RNA chaperone activity promote RNA folding by loosening the structure of misfolded RNAs or by preventing their formation. How these proteins achieve this activity is still unknown, the mechanism is not understood and it is unclear whether this activity is always based on the same mechanism or whether different RNA chaperones use different
Rajkowitsch, Lukas, Semrad, Katharina, Mayer, Oliver, Schroeder, Renée   +3 more
openaire   +3 more sources