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RNA Remodeling by RNA Chaperones Monitored by RNA Structure Probing
2019RNA structure probing enables the characterization of RNA secondary structures by established procedures such as the enzyme- or chemical-based detection of single- or double-stranded regions. A specific type of application involves the detection of changes of RNA structures and conformations that are induced by proteins with RNA chaperone activity ...
Susann, Friedrich +2 more
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RNA Chaperones Step Out of Hfq’s Shadow
Trends in Microbiology, 2017The stability and function of regulatory small RNAs (sRNAs) often require a specialized RNA-binding protein called an RNA chaperone. Recent findings show that proteins containing a ProQ/FinO domain constitute a new class of RNA chaperones that could play key roles in post-transcriptional gene regulation throughout bacterial species.
Attaiech, Laetitia +2 more
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The ubiquitous nature of RNA chaperone proteins
2002RNA chaperones are ubiquitous and abundant proteins found in all living organisms and viruses, where they interact with various classes of RNA. These highly diverse families of nucleic acid-binding proteins possess activities enabling rapid and faithful RNA-RNA annealing, strand transfer, and exchange and RNA ribozyme-mediated cleavage under ...
Gaël, Cristofari, Jean-Luc, Darlix
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Folding of the td pre-RNA with the help of the RNA chaperone StpA
Biochemical Society Transactions, 2002The td group I intron is inserted in the reading frame of the thymidylate synthase gene, which is mainly devoid of structural elements. In vivo, translation of the pre-mRNA is required for efficient folding of the intron into its splicing-competent structure.
Mayer, Oliver +3 more
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RNA‐Chaperone mit Breitbandwirkung
Chemie in unserer Zeit, 2008AbstractRNA‐Chaperone sind beim Entfalten der räumlichen Strukturen von Ribonucleinsäuren nicht wählerisch und können selbst die stabile native Konformation auflösen. Wie durch ihre Aktivität dennoch die funktionell bedeutsame native RNA‐Struktur begünstigt wird, zeigt die Untersuchung eines Ribozyms aus dem Schlauchpilz Neurospora crassa.
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Hfq: A Multifaceted RNA Chaperone Involved in Virulence
Future Microbiology, 2015Hfq has emerged in recent years as a master regulator of gene expression in bacteria, mainly due to its ability to mediate the interaction of small noncoding RNAs with their mRNA targets, including those related to virulence in Gram-negative bacteria.
Joana R, Feliciano +4 more
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The Roles of Chaperones in RNA Folding
2012Because of its limited structural diversity, RNA has a strong tendency to misfold, and the stability of local structure often causes misfolded conformations to be long-lived on the biological time scale. The effects of RNA misfolding are dealt with in vivo by chaperones.
Pilar Tijerina, Rick Russell
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RNA structural remodeling by RNA annealer proteins and RNA chaperones
2011As with all biological macromolecules, RNA molecules need to adopt distinct three-dimensional structures in order to complete their tasks inside the cell. Nevertheless, structural flexibility is a necessity for many RNAs that exist in more than one functional conformation and that need to adapt to environmental stimuli.
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