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RNA Chaperones Step Out of Hfq’s Shadow
Trends in Microbiology, 2017The stability and function of regulatory small RNAs (sRNAs) often require a specialized RNA-binding protein called an RNA chaperone. Recent findings show that proteins containing a ProQ/FinO domain constitute a new class of RNA chaperones that could play key roles in post-transcriptional gene regulation throughout bacterial species.
Attaiech, Laetitia +2 more
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FinO is an RNA chaperone that facilitates sense-antisense RNA interactions [PDF]
EMBO Journal, 2003 The protein FinO represses F-plasmid conjugative transfer by facilitating interactions between the mRNA of the major F-plasmid transcriptional activator, TraJ, and an antisense RNA, FinP. FinO is known to bind stem-loop structures in both FinP and traJ RNAs; however, the mechanism by which FinO facilitates sense-antisense pairing is poorly understood ...
Laura S Frost, J N Mark Glover
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RNA modification enzyme TruB is a tRNA chaperone [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance RNAs are intimately involved in numerous cellular functions such as gene expression. Typically, RNAs adopt a 3D fold, and their sequences may be chemically altered to contain modified nucleotides such as pseudouridines. There are many RNA modification enzymes, but often their cellular functions remain unknown.
Govardhan Reddy Veerareddygari +1 more
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RNA Remodeling by RNA Chaperones Monitored by RNA Structure Probing
2019RNA structure probing enables the characterization of RNA secondary structures by established procedures such as the enzyme- or chemical-based detection of single- or double-stranded regions. A specific type of application involves the detection of changes of RNA structures and conformations that are induced by proteins with RNA chaperone activity ...
Susann, Friedrich +2 more
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The FinO family of bacterial RNA chaperones
Plasmid, 2015Antisense RNAs have long been known to regulate diverse aspects of plasmid biology. Here we review the FinOP system that modulates F plasmid gene expression through regulation of the F plasmid transcription factor, TraJ. FinOP is a two component system composed of an antisense RNA, FinP, which represses TraJ translation, and a protein, FinO, which is ...
J N, Mark Glover +5 more
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RNA chaperone activity of translation initiation factor IF1
Biochimie, 2006Translation initiation factor IF1 is an indispensable protein for translation in prokaryotes. No clear function has been assigned to this factor so far. In this study we demonstrate an RNA chaperone activity of this protein both in vivo and in vitro. The chaperone assays are based on in vivo or in vitro splicing of the group I intron in the thymidylate
Lukas Rajkowitsch
exaly +5 more sources
RNA‐Chaperone mit Breitbandwirkung
Chemie in unserer Zeit, 2008AbstractRNA‐Chaperone sind beim Entfalten der räumlichen Strukturen von Ribonucleinsäuren nicht wählerisch und können selbst die stabile native Konformation auflösen. Wie durch ihre Aktivität dennoch die funktionell bedeutsame native RNA‐Struktur begünstigt wird, zeigt die Untersuchung eines Ribozyms aus dem Schlauchpilz Neurospora crassa.
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Hfq: a multifaceted RNA chaperone involved in virulence.
Future Microbiology, 2016Hfq has emerged in recent years as a master regulator of gene expression in bacteria, mainly due to its ability to mediate the interaction of small noncoding RNAs with their mRNA targets, including those related to virulence in Gram-negative bacteria.
J. Feliciano +4 more
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Fab Chaperone-Assisted RNA Crystallography (Fab CARC)
2016Recent discovery of structured RNAs such as ribozymes and riboswitches shows that there is still much to learn about the structure and function of RNAs. Knowledge learned can be employed in both biochemical research and clinical applications. X-ray crystallography gives unparalleled atomic-level structural detail from which functional inferences can be
Sherman, Eileen +2 more
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The ubiquitous nature of RNA chaperone proteins
2002RNA chaperones are ubiquitous and abundant proteins found in all living organisms and viruses, where they interact with various classes of RNA. These highly diverse families of nucleic acid-binding proteins possess activities enabling rapid and faithful RNA-RNA annealing, strand transfer, and exchange and RNA ribozyme-mediated cleavage under ...
Gaël, Cristofari, Jean-Luc, Darlix
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