Results 41 to 50 of about 2,163,835 (311)
PLoS Pathogens, 2015 RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism.
Hongjie Xia +12 more
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Transcription complexes as RNA chaperones [PDF]
Transcription, 2021 To exert their functions, RNAs adopt diverse structures, ranging from simple secondary to complex tertiary and quaternary folds. In vivo, RNA folding starts with RNA transcription, and a wide variety of processes are coupled to co-transcriptional RNA folding events, including the regulation of fundamental transcription dynamics, gene regulation by ...
Nelly Said, Markus C. Wahl
openaire +3 more sources
C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA
Proceedings of the National Academy of Sciences of the United States of America, 2016 Kumari Kavita +2 more
exaly +2 more sources
Heterotypic phase separation of Hfq is linked to its roles as an RNA chaperone.
Cell Reports, 2022 Hfq, an Sm-like protein and the major RNA chaperone in E. coli, has been shown to distribute non-uniformly along a helical path under normal growth conditions and to relocate to the cell poles under certain stress conditions.
Omer Goldberger +3 more
semanticscholar +1 more source
RNA Biology, 2016 Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity may contribute to the cellular response to stress.
Scott, Horowitz, James C A, Bardwell
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RNA chaperones encoded by RNA viruses [PDF]
Virologica Sinica, 2015 RNAs are functionally diverse macromolecules whose proper functions rely strictly upon their correct tertiary structures. However, because of their high structural flexibility, correct folding of RNAs is challenging and slow. Therefore, cells and viruses encode a variety of RNA remodeling proteins, including helicases and RNA chaperones. In RNA viruses,
Yang, Jie +3 more
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RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Rajkowitsch, Lukas +9 more
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The ribosome can prevent aggregation of partially folded protein intermediates: studies using the Escherichia coli ribosome. [PDF]
PLoS ONE, 2014 BACKGROUND: Molecular chaperones that support de novo folding of proteins under non stress condition are classified as chaperone 'foldases' that are distinct from chaperone' holdases' that provide high affinity binding platform for unfolded proteins and ...
Bani Kumar Pathak +3 more
doaj +1 more source
Cell Reports, 2020 Summary: Bacterial pathogens often employ RNA regulatory elements located in the 5′ untranslated regions (UTRs) to control gene expression. Using a comparative structural analysis, we examine the structure of 5′ UTRs at a global scale in the pathogenic ...
Dmitriy Ignatov +10 more
doaj +1 more source
SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine
Frontiers in Immunology, 2023 We have previously demonstrated that scavenger receptor A (SRA) acts as an immunosuppressive regulator of dendritic cell (DC) function in activating antitumor T cells.
Jie Qian +13 more
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