Results 41 to 50 of about 92,611 (279)
RNA Chaperones and the RNA Folding Problem [PDF]
Journal of Biological Chemistry, 1995 Functional and structural inter-relationships of RNA and proteins in the execution and control of biological processes such as RNA processing, RNA splicing, and translation are increasingly apparent. In this minireview, I present an RNA chaperone hypothesis, which fosters the view that constraints imposed by fundamental problems in the folding of RNA ...
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The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]
, 2012 Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K. +41 more
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Impacts of Small RNAs and Their Chaperones on Bacterial Pathogenicity [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Bacterial small RNAs (sRNAs) are critical post-transcriptional regulators that exert broad effects on cell physiology. One class of sRNAs, referred to as trans-acting sRNAs, base-pairs with mRNAs to cause changes in their stability or translation. Another class of sRNAs sequesters RNA-binding proteins that in turn modulate mRNA expression.
Louise Djapgne +2 more
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RNA Helicase Proteins as Chaperones and Remodelers [PDF]
Annual Review of Biochemistry, 2014 Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily broad set of functional roles. Central among these roles are the promotion of rearrangements of structured RNAs and the remodeling of ribonucleoprotein complexes (RNPs), allowing formation of native RNA structure or progression through a functional cycle of ...
Inga, Jarmoskaite, Rick, Russell
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Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]
, 2010 The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
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Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]
, 2013 : OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes.
Taylor, James E. +28 more
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The Spliceosome: The Ultimate RNA Chaperone and Sculptor [PDF]
Trends in Biochemical Sciences, 2016 The spliceosome, one of the most complex machineries of eukaryotic cells, removes intronic sequences from primary transcripts to generate functional messenger and long noncoding RNAs (lncRNA). Genetic, biochemical, and structural data reveal that the spliceosome is an RNA-based enzyme.
Panagiotis Papasaikas, Juan Valcárcel
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Cell Discovery, 2021 Endowing mesophilic microorganisms with high-temperature resistance is highly desirable for industrial microbial fermentation. Here, we report a cold-shock protein (CspL) that is an RNA chaperone protein from a lactate producing thermophile strain ...
Zikang Zhou +10 more
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An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae
Nature Communications, 2022 Small regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria.
Michaela Huber +8 more
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Chaperna: linking the ancient RNA and protein worlds
RNA Biology, 2021 As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst.
Ahyun Son, Scott Horowitz, Baik L. Seong
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