The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus. [PDF]
Nucleic Acids Res, 2018 RNA-binding proteins (RBPs) are essential to fine-tune gene expression. RBPs containing the cold-shock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for many of them remain elusive.
Caballero CJ +11 more
europepmc +2 more sources
The Spliceosome: The Ultimate RNA Chaperone and Sculptor. [PDF]
Trends in Biochemical Sciences, 2016 The spliceosome, one of the most complex machineries of eukaryotic cells, removes intronic sequences from primary transcripts to generate functional messenger and long noncoding RNAs (lncRNA).
Panagiotis K. Papasaikas, J. Valcárcel
semanticscholar +3 more sources
Nucleotide triphosphatase and RNA chaperone activities of murine norovirus NS3. [PDF]
J Gen Virol, 2018 Modulation of RNA structure is essential in the life cycle of RNA viruses. Immediate replication upon infection requires RNA unwinding to ensure that RNA templates are not in intra- or intermolecular duplex forms.
Han KR +7 more
europepmc +2 more sources
A Guanosine-Centric Mechanism for RNA Chaperone Function [PDF]
Science, 2013 Simply Folding RNA chaperones simplify what would otherwise be complex and slow RNA folding events. Grohman et al. (p. 190 , published online 7 March) show that the Moloney murine leukemia virus (MuLV) nucleocapsid (NC) protein, which ...
Jacob K, Grohman +6 more
openaire +4 more sources
Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding [PDF]
Biochemistry Research International, 2011 Proteins with RNA chaperone activity are ubiquitous proteins that play important roles in cellular mechanisms. They prevent RNA from misfolding by loosening misfolded structures without ATP consumption.
Katharina Semrad
doaj +2 more sources
The OB-fold proteins of the Trypanosoma brucei editosome execute RNA-chaperone activity. [PDF]
Nucleic Acids Res, 2018 Sequence-deficient mitochondrial pre-mRNAs in African trypanosomes are substrates of a U-nucleotide-specific RNA editing reaction to generate translation-competent mRNAs. The reaction is catalyzed by a macromolecular protein complex termed the editosome.
Voigt C +9 more
europepmc +2 more sources
Light-Triggered RNA Annealing by an RNA Chaperone [PDF]
Angewandte Chemie, 2015 Non-coding antisense RNAs regulate bacterial genes in response to nutrition or environmental stress, and can be engineered for artificial gene control. The RNA chaperone Hfq accelerates antisense pairing between non-coding RNAs and their mRNA targets, by
S. Panja +3 more
semanticscholar +3 more sources
The primary transcriptome of Neisseria meningitidis and its interaction with the RNA chaperone Hfq [PDF]
Nucleic Acids Research, 2017 Neisseria meningitidis is a human commensal that can also cause life-threatening meningitis and septicemia. Despite growing evidence for RNA-based regulation in meningococci, their transcriptome structure and output of regulatory small RNAs (sRNAs) are ...
Nadja Heidrich +5 more
semanticscholar +2 more sources
Lipid vesicles chaperone an encapsulated RNA aptamer [PDF]
Nature Communications, 2018 So far little is known about how encapsulation affects the activity and folding of RNA, which is of interest for understanding the origin of cellular life.
Ranajay Saha +2 more
doaj +5 more sources
Arabidopsis Disulfide Reductase, Trx-h2, Functions as an RNA Chaperone under Cold Stress
Applied Sciences, 2021 The thioredoxin-h (Trx-h) family of Arabidopsis thaliana comprises cytosolic disulfide reductases. However, the physiological function of Trx-h2, which contains an additional 19 amino acids at its N-terminus, remains unclear.
Eun Seon Lee +7 more
doaj +3 more sources