RNA Biology, 2022 In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and they support regulatory ...
Kai Katsuya-Gaviria +3 more
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RNA can function as molecular chaperone for RNA folding
Giant, 2020 RNAs can mimic the information storage, replication and catalysis functions of DNAs and proteins, providing physical evidence for the widely accepted RNA world hypothesis that RNA alone constitutes earlier life forms.
Zhi-Chao Lei +8 more
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Light-Triggered RNA Annealing by an RNA Chaperone. [PDF]
Angew Chem Int Ed Engl, 2015 AbstractNon‐coding antisense RNAs regulate bacterial genes in response to nutrition or environmental stress, and can be engineered for artificial gene control. The RNA chaperone Hfq accelerates antisense pairing between non‐coding RNAs and their mRNA targets, by a mechanism still unknown.
Panja S +3 more
europepmc +5 more sources
Structural and functional analysis of a plant nucleolar RNA chaperone-like protein [PDF]
Scientific Reports, 2023 Ribosome biogenesis is a key process in all eukaryotic cells that requires hundreds of ribosome biogenesis factors (RBFs), which are essential to build the mature ribosomes consisting of proteins and rRNAs.
Rita Fernandes +8 more
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Conserved TRAM Domain Functions as an Archaeal Cold Shock Protein via RNA Chaperone Activity
Frontiers in Microbiology, 2017 Cold shock proteins (Csps) enable organisms to acclimate to and survive in cold environments and the bacterial CspA family exerts the cold protection via its RNA chaperone activity.
Bo Zhang +10 more
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The bacterial endoribonuclease RNase E can cleave RNA in the absence of the RNA chaperone Hfq. [PDF]
J Biol Chem, 2019 RNase E is a component of the RNA degradosome complex and plays a key role in RNA degradation and maturation in Escherichia coli. RNase E–mediated target RNA degradation typically involves the RNA chaperone Hfq and requires small guide RNAs (sRNAs ...
Baek YM +6 more
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The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during mitotic exit enabling chromatin decondensation [PDF]
Nature CommunicationsDuring mitosis, chromosomes condense and decondense to segregate faithfully and undamaged. The exact molecular mechanisms are not well understood. We identify the DEAD-box helicase eIF4A1/2 as a critical factor in this process.
Ramona Jühlen +15 more
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The regulon of the RNA chaperone CspA and its auto-regulation in Staphylococcus aureus. [PDF]
Nucleic Acids Res, 2018 RNA-binding proteins (RBPs) are essential to fine-tune gene expression. RBPs containing the cold-shock domain are RNA chaperones that have been extensively studied. However, the RNA targets and specific functions for many of them remain elusive.
Caballero CJ +11 more
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Lipid vesicles chaperone an encapsulated RNA aptamer [PDF]
Nature Communications, 2018 So far little is known about how encapsulation affects the activity and folding of RNA, which is of interest for understanding the origin of cellular life.
Ranajay Saha +2 more
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Coordinate regulation of alternative pre-mRNA splicing events by the human RNA chaperone proteins hnRNPA1 and DDX5. [PDF]
Genes Dev, 2018 In this study, Lee et al. analyze pre-mRNA splicing patterns, RNA-binding sites, and RNA structures near these binding sites coordinately controlled by two splicing factors: the heterogeneous nuclear ribonucleoprotein hnRNPA1 and the RNA helicase DDX5 ...
Lee YJ, Wang Q, Rio DC.
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