Structural basis of rotavirus RNA chaperone displacement and RNA annealing. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Accurate RNA folding is essential for virus replication. Rotaviruses are viruses infecting humans and animals. Rotavirus genome comprises 11 distinct RNAs, and successful replication requires the incorporation of all 11 RNAs into a virion ...
Bravo JPK +10 more
europepmc +12 more sources
The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis. [PDF]
PLoS Genetics, 2019 TRAM is a conserved domain among RNA modification proteins that are widely distributed in various organisms. In Archaea, TRAM occurs frequently as a standalone protein with in vitro RNA chaperone activity; however, its biological significance and ...
Jie Li +8 more
doaj +3 more sources
RNA Biology, 2022 In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and they support regulatory ...
Kai Katsuya-Gaviria +3 more
doaj +5 more sources
Acidic C-terminal domains autoregulate the RNA chaperone Hfq [PDF]
eLife, 2017 The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial small RNAs (sRNAs) and mRNAs involved in stress response and pathogenesis. Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function
Andrew Santiago-Frangos +3 more
doaj +3 more sources
RNA can function as molecular chaperone for RNA folding
Giant, 2020 RNAs can mimic the information storage, replication and catalysis functions of DNAs and proteins, providing physical evidence for the widely accepted RNA world hypothesis that RNA alone constitutes earlier life forms.
Zhi-Chao Lei +8 more
doaj +4 more sources
The RGG/RG motif of AUF1 isoform p45 is a key modulator of the protein’s RNA chaperone and RNA annealing activities [PDF]
RNA Biology, 2019 The RNA-binding protein AUF1 regulates post-transcriptional gene expression by affecting the steady state and translation levels of numerous target RNAs.
Susann Friedrich +2 more
exaly +3 more sources
Functional Characterization of Acinetobacter baumannii Lacking the RNA Chaperone Hfq [PDF]
Frontiers in Microbiology, 2017 The RNA chaperone Hfq is involved in the riboregulation of diverse genes via small RNAs. Recent studies have demonstrated that Hfq contributes to the stress response and the virulence of several pathogens, and the roles of Hfq vary among bacterial ...
Han-Yueh Kuo +9 more
doaj +3 more sources
Crosstalk between the tRNA methyltransferase Trm1 and RNA chaperone La influences eukaryotic tRNA maturation. [PDF]
J Biol Chem, 2023 tRNAs undergo an extensive maturation process involving post-transcriptional modifications often associated with tRNA structural stability and promoting the native fold.
Porat J +5 more
europepmc +2 more sources
Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry. [PDF]
Proc Natl Acad Sci U S A, 2022 RNA-binding proteins contain intrinsically disordered regions whose functions in RNA recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains six flexible C-terminal domains (CTDs). The effect of the CTDs on Hfq’s integrity
Sarni SH +8 more
europepmc +2 more sources
Silencing of natural transformation by an RNA chaperone and a multitarget small RNA [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Natural transformation is a major mechanism of horizontal gene transfer (HGT) by which bacteria take up exogenous DNA directly in their environment and integrate it in their genome. Acquiring new genetic information may confer an adaptive advantage but an uncontrolled uptake of foreign DNA may be ...
Xavier Charpentier +2 more
exaly +6 more sources