Results 1 to 10 of about 2,163,835 (311)

Intermolecular Communication in Bacillus subtilis: RNA-RNA, RNA-Protein and Small Protein-Protein Interactions

Frontiers in Molecular Biosciences, 2020
In bacterial cells we find a variety of interacting macromolecules, among them RNAs and proteins. Not only small regulatory RNAs (sRNAs), but also small proteins have been increasingly recognized as regulators of bacterial gene expression.
Inam Ul Haq, Peter Müller, Sabine Brantl   +2 more
doaj   +1 more source

NF90–NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity

Nucleic Acids Research, 2017
The heterodimer NF90–NF45 is an RNA-binding protein complex that modulates the expression of various cellular mRNAs on the post-transcriptional level. Furthermore, it acts as a host factor that supports the replication of several RNA viruses.
Tobias Schmidt, S. Friedrich, R. Golbik, S. Behrens   +3 more
semanticscholar   +1 more source

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

Haematologica, 2013
Despite therapeutic advances multiple myeloma remains largely incurable, and novel therapeutic concepts are needed. The Hsp90-chaperone is a reasonable therapeutic target, because it maintains oncogenic signaling of multiple deregulated pathways. However,
Manik Chatterjee, Mindaugas Andrulis, Thorsten Stühmer, Elisabeth Müller, Claudia Hofmann, Torsten Steinbrunn, Tanja Heimberger, Heike Schraud, Stefanie Kressmann, Hermann Einsele, Ralf C. Bargou   +10 more
doaj   +1 more source

RNA Chaperone Function of a Universal Stress Protein in Arabidopsis Confers Enhanced Cold Stress Tolerance in Plants

International Journal of Molecular Sciences, 2017
The physiological function of Arabidopsis thaliana universal stress protein (AtUSP) in plant has remained unclear. Thus, we report here the functional role of the Arabidopsis universal stress protein, AtUSP (At3g53990).
S. M. B. Melencion, Y. Chi, Thuy Pham, Seol Ki Paeng, Seong Dong Wi, Chan-goo Lee, S. Ryu, S. Koo, S. Y. Lee   +8 more
semanticscholar   +1 more source

Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq

Scientific Reports, 2017
The RNA-chaperone Hfq catalyses the annealing of bacterial small RNAs (sRNAs) with target mRNAs to regulate gene expression in response to environmental stimuli.
E. Schulz, Markus Seiler, C. Zuliani, F. Voigt, V. Rybin, V. Pogenberg, Norbert Mücke, M. Wilmanns, T. Gibson, O. Barabas   +9 more
semanticscholar   +1 more source

Synthetic biology tools to promote the folding and function of RNA aptamers in mammalian cells

RNA Biology, 2023
RNA aptamers are structured RNAs that can bind to diverse ligands, including proteins, metabolites, and other small molecules. RNA aptamers are widely used as in vitro affinity reagents.
Qian Hou, Samie R. Jaffrey
doaj   +1 more source

RNA-dependent proteome solubility maintenance in Escherichia coli lysates analysed by quantitative mass spectrometry: Proteomic characterization in terms of isoelectric point, structural disorder, functional hub, and chaperone network

RNA Biology
Protein aggregation, a consequence of misfolding and impaired proteostasis, can lead to cellular malfunctions such as various proteinopathies.
Chan Park, Bitnara Han, Yura Choi, Yoontae Jin, Kwang Pyo Kim, Seong Il Choi, Baik L. Seong   +6 more
doaj   +1 more source

The RNA Chaperone Hfq Is Essential for Virulence and Modulates the Expression of Four Adhesins in Yersinia enterocolitica

Scientific Reports, 2016
In Enterobacteriaceae, the RNA chaperone Hfq mediates the interaction of small RNAs with target mRNAs, thereby modulating transcript stability and translation.
T. Kakoschke, S. Kakoschke, Catharina Zeuzem, H. Bouabe, K. Adler, J. Heesemann, Ombeline Rossier   +6 more
semanticscholar   +1 more source

No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureus

BMC Microbiology, 2007
Background The RNA-binding protein Hfq is involved in stress and virulence of several pathogens, probably due to its role as mediator in small RNA (sRNA)-mRNA interactions.
Bouloc Philippe, Rigoulay Candice, Bohn Chantal   +2 more
doaj   +1 more source

OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa

Genes, 2016
The metal-specific CzcRS two-component system in Pseudomonas aeruginosa is involved in the repression of the OprD porin, causing in turn carbapenem antibiotic resistance in the presence of high zinc concentration. It has also been shown that CzcR is able
Verena Ducret, Manuel R. Gonzalez, Tiziana Scrignari, K. Perron   +3 more
semanticscholar   +1 more source