Results 41 to 50 of about 331,295 (252)
Cleavage of an RNA Model Compound by an Arylmercury Complex [PDF]
ChemBioChem, 2021 AbstractA water‐soluble arylmercury complex has been synthesized, and its ability to catalyze the cleavage of the phosphodiester linkage of the RNA model compound adenylyl‐3′,5′‐(2′,3′‐O‐methyleneadenosine) has been assessed over a pH range of 3–8.5 and a catalyst concentration range of 0–7 mM.
Lange Yakubu Saleh +2 more
openaire +3 more sources
Enzymatic cleavage of RNA by RNA
Bioscience Reports, 1990 The discovery and characterization of the catalytic RNA subunit of the enzyme ribonuclease P of Escherichia coli is described.
openaire +1 more source
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex [PDF]
Cell, 2009 Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from viruses and other potential genome invaders. This adaptive prokaryotic immune system arises from the clustered regularly interspaced short palindromic repeats (CRISPRs) found in prokaryotic genomes, which harbor short invader-derived sequences, and the CRISPR-associated (
Hale, Caryn R. +7 more
openaire +2 more sources
CFIm25 in Solid Tumors: Current Research Progress
Technology in Cancer Research & Treatment, 2020 Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized.
Xiaojie Sun MD, PhD +4 more
doaj +1 more source
Enhancement of RNA self‐cleavage by micellar catalysis [PDF]
FEBS Letters, 1999 It has been reported recently that naturally occurring catalytic RNAs like hammerhead and hairpin ribozyme do not require metal ions for efficient catalysis. It seems that the folded tertiary structure of the RNA contributes more to the catalytic function than was initially recognized.
Riepe, Andrea +2 more
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. [PDF]
PLoS ONE, 2017 CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids.
Tina Y Liu +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source