Results 31 to 40 of about 331,295 (252)
Regulation of coronavirus nsp15 cleavage specificity by RNA structure
PLoS ONE, 2023 SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, has had an enduring impact on global public health. However, SARS-CoV-2 is only one of multiple pathogenic human coronaviruses (CoVs) to have emerged since the turn of the century. CoVs encode for
Indraneel Salukhe +4 more
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Characterization of MazF-Mediated Sequence-Specific RNA Cleavage in Pseudomonas putida Using Massive Parallel Sequencing. [PDF]
PLoS ONE, 2016 Under environmental stress, microbes are known to alter their translation patterns using sequence-specific endoribonucleases that we call RNA interferases. However, there has been limited insight regarding which RNAs are specifically cleaved by these RNA
Tatsuki Miyamoto +4 more
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Frontiers in Bioinformatics, 2022 The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott +5 more
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RNase P RNA‐mediated cleavage [PDF]
IUBMB Life, 2009 AbstractMetal(II)‐induced hydrolysis of RNA produce products with 5′‐hydroxyls and 2′;3′‐cyclic phosphates at the ends. Ribozymes are RNA molecules that act as catalysts. Some ribozymes that cleave RNA also generate 5′‐hydroxyls and 2′;3′‐cyclic phosphates whereas others produces 5′‐phosphates and 3′‐hydroxyls at the ends of the cleavage products ...
Leif A, Kirsebom, Stefan, Trobro
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Regulating gene expression in animals through RNA endonucleolytic cleavage
Heliyon, 2018 The expression of any gene must be precisely controlled for appropriate function. This expression can be controlled at various levels. This includes epigenetic regulation through DNA methylation or histone modifications. At the posttranscriptional level,
Karen Gu, Lawrence Mok, Mark M.W. Chong
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Acta Biochimica et Biophysica Sinica, 2023 Argonaute (Ago) proteins are conserved programmable nucleases present in eukaryotes and prokaryotes and provide defense against mobile genetic elements. Almost all characterized pAgos prefer to cleave DNA targets.
Liu Qi +7 more
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Intracellular RNA cleavage by the hairpin ribozyme [PDF]
Nucleic Acids Research, 1998 Studies involving ribozyme-directed inactivation of targeted RNA molecules have met with mixed success, making clear the importance of methods to measure and optimize ribozyme activity within cells. The interpretation of biochemical assays for determining ribozyme activity in the cellular environment have been complicated by recent results indicating ...
A A, Seyhan, J, Amaral, J M, Burke
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Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes
Molecules, 2019 Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge
Olivia Luige +3 more
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Transcriptome wide annotation of eukaryotic RNase III reactivity and degradation signals. [PDF]
PLoS Genetics, 2015 Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and biochemical annotations of the signals required for
Jules Gagnon +4 more
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Binding and cleavage of CRISPR RNA by Cas6 [PDF]
RNA, 2010 The CRISPR–Cas system provides many prokaryotes with acquired resistance to viruses and other mobile genetic elements. The core components of this defense system are small, host-encoded prokaryotic silencing (psi)RNAs and Cas (CRISPR-associated) proteins.
Jason, Carte +4 more
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