Results 31 to 40 of about 1,323,554 (297)

Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]

, 2008
Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core   +1 more source

Crystal structure of the 25 kDa subunit of human cleavage factor Im [PDF]

, 2008
Cleavage factor I(m) is an essential component of the pre-messenger RNA 3'-end processing machinery in higher eukaryotes, participating in both the polyadenylation and cleavage steps. Cleavage factor I(m) is an oligomer composed of a small 25 kDa subunit
Martin., G., Coseno, M., Doublié, S., Molly Coseno, Sylvie Doublié, Georges Martin, Gilmartin, G., Keller, W., Gregory Gilmartin, Walter Keller, Christopher Berger, Berger, C., Doublié, Sylvie, Berger, Christopher, Coseno, Molly, Martin, Georges, Gilmartin, Gregory, Keller, Walter   +17 more
core   +2 more sources

Endonucleolytic RNA cleavage by a eukaryotic exosome [PDF]

Nature, 2008
The exosome is a major eukaryotic nuclease located in both the nucleus and the cytoplasm that contributes to the processing, quality control and/or turnover of a large number of cellular RNAs. This large macromolecular assembly has been described as a 3'-->5' exonuclease and shown to contain a nine-subunit ring structure evolutionarily related to ...
Lebreton, Alice, Tomecki, Rafal, Dziembowski, Andrzej, Séraphin, Bertrand   +3 more
openaire   +3 more sources

Regulating gene expression in animals through RNA endonucleolytic cleavage

Heliyon, 2018
The expression of any gene must be precisely controlled for appropriate function. This expression can be controlled at various levels. This includes epigenetic regulation through DNA methylation or histone modifications. At the posttranscriptional level,
Karen Gu, Lawrence Mok, Mark M.W. Chong
doaj   +1 more source

Structural Requirements in the Hemagglutinin Cleavage Site-Coding RNA Region for the Generation of Highly Pathogenic Avian Influenza Virus

Pathogens, 2021
Highly pathogenic avian influenza viruses (HPAIVs) with H5 and H7 hemagglutinin (HA) subtypes are derived from their low pathogenic counterparts following the acquisition of multiple basic amino acids in their HA cleavage site. It has been suggested that
Yurie Kida, Kosuke Okuya, Takeshi Saito, Junya Yamagishi, Aiko Ohnuma, Takanari Hattori, Hiroko Miyamoto, Rashid Manzoor, Reiko Yoshida, Naganori Nao, Masahiro Kajihara, Tokiko Watanabe, Ayato Takada   +12 more
doaj   +1 more source

RNA Cleavage Linked With Ribosomal Action [PDF]

Genetics, 2005
Abstract Ribonuclease LS in Escherichia coli is a potential antagonist of bacteriophage T4. When T4 dmd is mutated, this RNase efficiently cleaves T4 mRNAs and leads to the silencing of late genes, thus blocking T4 growth. We previously found that, when two consecutive ochre codons were placed in the open reading frame of T4 soc, RNase ...
Haruyo, Yamanishi, Tetsuro, Yonesaki
openaire   +2 more sources

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences

Frontiers in Bioinformatics, 2022
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott, Rebecca J. Pawluk, Anna V. Protasio, Ruth Y. Akinmusola, Dominika Lastik, Vicky L. Hunt   +5 more
doaj   +1 more source

RNase P RNA‐mediated cleavage [PDF]

IUBMB Life, 2009
AbstractMetal(II)‐induced hydrolysis of RNA produce products with 5′‐hydroxyls and 2′;3′‐cyclic phosphates at the ends. Ribozymes are RNA molecules that act as catalysts. Some ribozymes that cleave RNA also generate 5′‐hydroxyls and 2′;3′‐cyclic phosphates whereas others produces 5′‐phosphates and 3′‐hydroxyls at the ends of the cleavage products ...
Leif A, Kirsebom, Stefan, Trobro
openaire   +3 more sources

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula, Rüegsegger U, Martin G, Chari A, Neuenkirchen N, Fischer U, Keller W, Blank D, Dettwiler S, Ostareck-Lederer A   +35 more
core   +1 more source

Further Probing of Cu²⁺-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes

Molecules, 2019
Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu2+ ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge
Olivia Luige, Merita Murtola, Alice Ghidini, Roger Strömberg   +3 more
doaj   +1 more source