Results 21 to 30 of about 331,295 (252)
Transfer RNA Cleavages by Onconase Reveal Unusual Cleavage Sites [PDF]
Journal of Biological Chemistry, 2006 Onconase, a protein from amphibian eggs and a homologue of pancreatic ribonuclease (RNase) superfamily, is cytotoxic, exhibits antitumor and antiviral activity, and is in phase III clinical trials. It has been shown to predominantly target cellular tRNA on its entry into mammalian cells (Saxena, S. K., Sirdeshmukh, R., Ardelt, W., Mikulski, S.
Avvaru N, Suhasini, Ravi, Sirdeshmukh
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Heliyon, 2023 Cuproptosis is a novel form of programmed cell death. The role and mechanism of cuproptosis-related genes in prostate adenocarcinoma have not been fully understood. In this study, a series of bioinformatic analyses were performed.
Shuyuan Xiao, Weiyang Lou
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Bioengineering, 2023 Conserved omicron RNA (COR) is a 40 base long 99.9% conserved sequence in SARS-CoV-2 Omicron variant, predicted to form a stable stem loop, the targeted cleavage of which can be an ideal next step in controlling the spread of variants.
Lindy G. Karrer +4 more
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Enzymatic cleavage of RNA by RNA
Trends in Biochemical Sciences, 1986 The discovery and characterization of the catalytic RNA subunit of the enzyme ribonuclease P ofEscherichia coli is described.
Sidney Altman +3 more
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Evolution of the R2 retrotransposon ribozyme and its self-cleavage site. [PDF]
PLoS ONE, 2013 R2 is a non-long terminal repeat retrotransposon that inserts site-specifically in the tandem 28S rRNA genes of many animals. Previously, R2 RNA from various species of Drosophila was shown to self-cleave from the 28S rRNA/R2 co-transcript by a hepatitis
Danna G Eickbush +2 more
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Cleavage-based signal amplification of RNA [PDF]
Nature Communications, 2013 RNA detection has become an integral part of current biomedical research. Up to now, the reverse transcription-PCR has been the most practical method to detect mRNA targets. However, RNA detection by reverse transcription-PCR requires sophisticated equipment and it is highly sensitive to contamination with genomic DNA.
Yongyun, Zhao, Li, Zhou, Zhuo, Tang
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RNA Cleavage Linked With Ribosomal Action [PDF]
Genetics, 2005 Abstract Ribonuclease LS in Escherichia coli is a potential antagonist of bacteriophage T4. When T4 dmd is mutated, this RNase efficiently cleaves T4 mRNAs and leads to the silencing of late genes, thus blocking T4 growth. We previously found that, when two consecutive ochre codons were placed in the open reading frame of T4 soc, RNase ...
Haruyo, Yamanishi, Tetsuro, Yonesaki
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Nucleic Acids Research, 1987 Using complementary chimeric oligonucleotides containing deoxyribonucleotides and 2'-O-methylribonucleotides (1), enzymatically synthesized RNA (90 mer) were cleaved at a single site with Escherichia coli RNaseH, either at a hairpin loop or at a stem region.
S, Shibahara +5 more
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Pathogens, 2021 Highly pathogenic avian influenza viruses (HPAIVs) with H5 and H7 hemagglutinin (HA) subtypes are derived from their low pathogenic counterparts following the acquisition of multiple basic amino acids in their HA cleavage site. It has been suggested that
Yurie Kida +12 more
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Endonucleolytic RNA cleavage by a eukaryotic exosome [PDF]
Nature, 2008 The exosome is a major eukaryotic nuclease located in both the nucleus and the cytoplasm that contributes to the processing, quality control and/or turnover of a large number of cellular RNAs. This large macromolecular assembly has been described as a 3'-->5' exonuclease and shown to contain a nine-subunit ring structure evolutionarily related to ...
Lebreton, Alice +3 more
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