Results 21 to 30 of about 1,323,554 (297)
Heliyon, 2023 Cuproptosis is a novel form of programmed cell death. The role and mechanism of cuproptosis-related genes in prostate adenocarcinoma have not been fully understood. In this study, a series of bioinformatic analyses were performed.
Shuyuan Xiao, Weiyang Lou
doaj +1 more source
Evaluation of the effect of RNA secondary structure on Cas13d-mediated target RNA cleavage. [PDF]
Mol Ther Nucleic AcidsThe clustered regularly interspaced short palindromic repeats (CRISPR)-Cas13d system was adapted as a powerful tool for targeting viral RNA sequences, making it a promising approach for antiviral strategies.
Hussein M +6 more
europepmc +2 more sources
Transfer RNA Cleavages by Onconase Reveal Unusual Cleavage Sites [PDF]
Journal of Biological Chemistry, 2006 Onconase, a protein from amphibian eggs and a homologue of pancreatic ribonuclease (RNase) superfamily, is cytotoxic, exhibits antitumor and antiviral activity, and is in phase III clinical trials. It has been shown to predominantly target cellular tRNA on its entry into mammalian cells (Saxena, S. K., Sirdeshmukh, R., Ardelt, W., Mikulski, S.
Avvaru N, Suhasini, Ravi, Sirdeshmukh
openaire +2 more sources
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation [PDF]
, 2003 Cleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle.
Sadowski, Martin +11 more
core +2 more sources
Enzymatic cleavage of RNA by RNA
Trends in Biochemical Sciences, 1986 The discovery and characterization of the catalytic RNA subunit of the enzyme ribonuclease P ofEscherichia coli is described.
Sidney Altman +3 more
openaire +1 more source
Evolution of the R2 retrotransposon ribozyme and its self-cleavage site. [PDF]
PLoS ONE, 2013 R2 is a non-long terminal repeat retrotransposon that inserts site-specifically in the tandem 28S rRNA genes of many animals. Previously, R2 RNA from various species of Drosophila was shown to self-cleave from the 28S rRNA/R2 co-transcript by a hepatitis
Danna G Eickbush +2 more
doaj +1 more source
Bioengineering, 2023 Conserved omicron RNA (COR) is a 40 base long 99.9% conserved sequence in SARS-CoV-2 Omicron variant, predicted to form a stable stem loop, the targeted cleavage of which can be an ideal next step in controlling the spread of variants.
Lindy G. Karrer +4 more
doaj +1 more source
Nucleic Acids Research, 1987 Using complementary chimeric oligonucleotides containing deoxyribonucleotides and 2'-O-methylribonucleotides (1), enzymatically synthesized RNA (90 mer) were cleaved at a single site with Escherichia coli RNaseH, either at a hairpin loop or at a stem region.
S, Shibahara +5 more
openaire +3 more sources
Multiple nucleic acid cleavage modes in divergent type III CRISPR systems [PDF]
, 2016 CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting ...
Zhang, Jing +6 more
core +1 more source
Binding and cleavage of CRISPR RNA by Cas6 [PDF]
RNA, 2010 The CRISPR–Cas system provides many prokaryotes with acquired resistance to viruses and other mobile genetic elements. The core components of this defense system are small, host-encoded prokaryotic silencing (psi)RNAs and Cas (CRISPR-associated) proteins.
Jason, Carte +4 more
openaire +2 more sources